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Pregled bibliografske jedinice broj: 846564

Can Crystal Symmetry and Packing Influence the Active Site Conformation of Homohexameric Purine Nucleoside Phosphorylases?


Luić, Marija; Štefanić, Zoran
Can Crystal Symmetry and Packing Influence the Active Site Conformation of Homohexameric Purine Nucleoside Phosphorylases? // Croatica chemica acta, 89 (2016), 2; 197-202 doi:10.5562/cca2872 (međunarodna recenzija, članak, znanstveni)


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Naslov
Can Crystal Symmetry and Packing Influence the Active Site Conformation of Homohexameric Purine Nucleoside Phosphorylases?

Autori
Luić, Marija ; Štefanić, Zoran

Izvornik
Croatica chemica acta (0011-1643) 89 (2016), 2; 197-202

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
crystal symmetry ; crystal packing ; active site conformation ; enzyme reaction ; purine nucleoside phosphorylase

Sažetak
It is generaly believed that enzymes retain most of their functionality in the crystal form due to the large solvent content of protein crystals. This is facilitated by the fact that their natural environment in solution is not too far from the one found in the crystal form. Nevertheless, if the nature of the enzyme is such to require conformational changes, overcoming of the crystal packing constraints may prove to be too difficult. Such conformational change is present in one class of enzymes (purine nucleoside phosphorylases), that is the subject of our scientific interest for many years. The influence of crystal symmetry and crystal packing on the conformation of the active sites in the case of homohexameric purine nucleoside phosphorylases is presented and analysed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Računarstvo



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-7423 - Enzimi purinskog reciklirajućeg ciklusa iz Helicobacter pylori i Escherichie coli (Marija Luić, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Marija Luić (autor)

Avatar Url Zoran Štefanić (autor)

Citiraj ovu publikaciju

Luić, Marija; Štefanić, Zoran
Can Crystal Symmetry and Packing Influence the Active Site Conformation of Homohexameric Purine Nucleoside Phosphorylases? // Croatica chemica acta, 89 (2016), 2; 197-202 doi:10.5562/cca2872 (međunarodna recenzija, članak, znanstveni)
Luić, M. & Štefanić, Z. (2016) Can Crystal Symmetry and Packing Influence the Active Site Conformation of Homohexameric Purine Nucleoside Phosphorylases?. Croatica chemica acta, 89 (2), 197-202 doi:10.5562/cca2872.
@article{article, year = {2016}, pages = {197-202}, DOI = {10.5562/cca2872}, keywords = {crystal symmetry, crystal packing, active site conformation, enzyme reaction, purine nucleoside phosphorylase}, journal = {Croatica chemica acta}, doi = {10.5562/cca2872}, volume = {89}, number = {2}, issn = {0011-1643}, title = {Can Crystal Symmetry and Packing Influence the Active Site Conformation of Homohexameric Purine Nucleoside Phosphorylases?}, keyword = {crystal symmetry, crystal packing, active site conformation, enzyme reaction, purine nucleoside phosphorylase} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI


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