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Pregled bibliografske jedinice broj: 845334

Radioprotection of the brain white matter by Mn(III) N-butoxyethylpyridylporphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5+


Weitzel, DH; Tovmasyan, Artak; Ashcraft, KA; Rajic, Zrinka; Weitner, Tin; Liu, C; Li, W; Buckley, AF; Prasad, MR; Young, KH et al.
Radioprotection of the brain white matter by Mn(III) N-butoxyethylpyridylporphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5+ // Molecular cancer therapeutics, 14 (2015), 70-79 doi:10.1158/1535-7163 (međunarodna recenzija, članak, znanstveni)


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Naslov
Radioprotection of the brain white matter by Mn(III) N-butoxyethylpyridylporphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5+

Autori
Weitzel, DH ; Tovmasyan, Artak ; Ashcraft, KA ; Rajic, Zrinka ; Weitner, Tin ; Liu, C ; Li, W ; Buckley, AF ; Prasad, MR ; Young, KH ; Rodriguiz, RM ; Wetsel, WC ; Peters, KB ; Spasojevic, Ivan ; Herndon II, JE ; Batinic Haberle, Ines ; Dewhirst, MW

Izvornik
Molecular cancer therapeutics (1535-7163) 14 (2015); 70-79

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Mn porphyrin ; MnTnBuOE-2-PyP5+ ; brain tumor ; radiation therapy

Sažetak
Cranial irradiation is a standard therapy for primary and metastatic brain tumors. A major drawback of radiotherapy (RT), however, is long-term cognitive loss that affects quality of life. Radiation-induced oxidative stress in normal brain tissue is thought to contribute to cognitive decline. We evaluated the effectiveness of a novel mimic of superoxide dismutase enzyme (SOD), MnTnBuOE-2- PyP5þ(Mn(III) meso-tetrakis(Nn- butoxyethylpyridinium-2-yl)porphyrin), to provide longterm neuroprotection following 8 Gy of whole brain irradiation. Long-term RT damage can only be assessed by brain imaging and neurocognitive studies. C57BL/6J mice were treated with MnTnBuOE-2-PyP5þ before and after RT and evaluated threemonths later. At this time point, drug concentration in the brain was 25 nmol/L. Mice treated with MnTnBuOE-2-PyP5+/ RT exhibited MRI evidence for myelin preservation in the corpus callosum compared with saline/RT treatment. Corpus callosum histology demonstrated a significant loss of axons in the saline/RT group that was rescued in the MnTnBuOE-2- PyP5+/RT group. In addition, the saline/RT groups exhibited deficits in motor proficiency as assessed by the rotorod test and running wheel tests. These deficits were ameliorated in groups treated with MnTnBuOE-2-PyP5þ/RT. Our data demonstrate that MnTnBuOE-2-PyP5+ is neuroprotective for oxidative stress damage caused by radiation exposure. In addition, glioblastoma cells were not protected by MnTnBuOE-2-PyP5+ combination with radiation in vitro. Likewise, the combination of MnTnBuOE-2-PyP5+ with radiation inhibited tumor growth more than RT alone in flank tumors. In summary, MnTnBuOE-2-PyP5+ has dual activity as a neuroprotector and a tumor radiosensitizer. Thus, it is an attractive candidate for adjuvant therapy with RT in future studies with patients with brain cancer.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Zrinka Rajić (autor)

Avatar Url Ines Batinić-Haberle (autor)

Avatar Url Tin Weitner (autor)

Citiraj ovu publikaciju

Weitzel, DH; Tovmasyan, Artak; Ashcraft, KA; Rajic, Zrinka; Weitner, Tin; Liu, C; Li, W; Buckley, AF; Prasad, MR; Young, KH et al.
Radioprotection of the brain white matter by Mn(III) N-butoxyethylpyridylporphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5+ // Molecular cancer therapeutics, 14 (2015), 70-79 doi:10.1158/1535-7163 (međunarodna recenzija, članak, znanstveni)
Weitzel, D., Tovmasyan, A., Ashcraft, K., Rajic, Z., Weitner, T., Liu, C., Li, W., Buckley, A., Prasad, M. & Young, K. (2015) Radioprotection of the brain white matter by Mn(III) N-butoxyethylpyridylporphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5+. Molecular cancer therapeutics, 14, 70-79 doi:10.1158/1535-7163.
@article{article, year = {2015}, pages = {70-79}, DOI = {10.1158/1535-7163}, keywords = {Mn porphyrin, MnTnBuOE-2-PyP5+, brain tumor, radiation therapy}, journal = {Molecular cancer therapeutics}, doi = {10.1158/1535-7163}, volume = {14}, issn = {1535-7163}, title = {Radioprotection of the brain white matter by Mn(III) N-butoxyethylpyridylporphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5+}, keyword = {Mn porphyrin, MnTnBuOE-2-PyP5+, brain tumor, radiation therapy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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