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The pattern of protein phosphorylation in various Streptomyces rimosus oxytetracycline producers’ strains (CROSBI ID 641697)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Paradžik Tina ; Šarić Ela ; Mikoč Andreja ; Maček Boris ; Herron Paul ; Hunter Ian ; Vujaklija Dušica The pattern of protein phosphorylation in various Streptomyces rimosus oxytetracycline producers’ strains. 2016

Podaci o odgovornosti

Paradžik Tina ; Šarić Ela ; Mikoč Andreja ; Maček Boris ; Herron Paul ; Hunter Ian ; Vujaklija Dušica

engleski

The pattern of protein phosphorylation in various Streptomyces rimosus oxytetracycline producers’ strains

Streptomyces species are multicellular bacteria that exhibit a complex developmental program and morphological differentiation. The great majority of natural products are synthesized by these bacteria. These natural products include clinically-important antibiotics (tetracyclines, streptomycins, & β-lactams), immunosuppressants and anti-cancer drugs (doxorubicin). The tetracyclines are one of the most successful classes of antibiotics that include oxytetracycline (OTC) produced by S. rimosus. It has been already reported that protein phosphorylation has an important role in the regulation of metabolism and antibiotic production in strepomycetes. Bioinformatic analysis of the S. coelicolor genome predicted 47 eukaryotic-like protein kinases and 49 eukaryotic type protein phosphatases in this species. This number of kinases, although larger than other bacteria is not surprising as the average Streptomyces genome size is almost twice that of E.coli. Based on the phosphoproteome reported for S. coelicolor we predict that the effect of the OTC overproduction in S. rimosus is a consequence of alteration in posttranslational modification (PTM) of regulatory and/or OTC biosynthesis proteins.

Streptomyces; Phosphorylation

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Podaci o prilogu

2016.

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objavljeno

Podaci o matičnoj publikaciji

Podaci o skupu

The 2nd International Conference on Post- Translational Modifications in Bacteria

poster

18.10.2016-21.10.2016

Lyon, Francuska

Povezanost rada

Biotehnologija