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Pregled bibliografske jedinice broj: 843834

Canonical Wnt/β-Catenin Signaling Pathway Is Dysregulated in Patients With Primary and Secondary Myelofibrosis


Lucijanić, Marko; Livun, Ana; Tomasović- Lončarić, Čedna; Štoos-Veić, Tajana; Pejša, Vlatko; Jakšić, Ozren; Prka, Željko; Kušec, Rajko
Canonical Wnt/β-Catenin Signaling Pathway Is Dysregulated in Patients With Primary and Secondary Myelofibrosis // Clinical Lymphoma Myeloma & Leukemia, 16 (2016), 9; 523-526 doi:10.1016/j.clml.2016.06.004 (međunarodna recenzija, članak, znanstveni)


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Naslov
Canonical Wnt/β-Catenin Signaling Pathway Is Dysregulated in Patients With Primary and Secondary Myelofibrosis

Autori
Lucijanić, Marko ; Livun, Ana ; Tomasović- Lončarić, Čedna ; Štoos-Veić, Tajana ; Pejša, Vlatko ; Jakšić, Ozren ; Prka, Željko ; Kušec, Rajko

Izvornik
Clinical Lymphoma Myeloma & Leukemia (2152-2650) 16 (2016), 9; 523-526

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Philadelphia chromosome-negative myeloproliferative neoplasm ; anemia ; RT PCR ; fibrosis ; JAK2 V617F

Sažetak
Activation of the canonical wingless-related integration site (Wnt)/b-catenin signaling pathway is associated with malignant transformation, development of fibrosis, and angiogenesis. We analyzed b- catenin mRNA expression in bone marrow of 29 patients with primary (PMF), 4 with secondary (SMF) myelofibrosis, and 16 control participants using quantitative real- time polymerase chain reaction (qRT PCR). b- Catenin expression is increased in PMF and SMF and might potentiate anemia. Introduction: b-Catenin is a central effector molecule of the canonical wingless- related integration site (Wnt) signaling pathway. It is important for maintenance of stem cell homeostasis and its aberrant activation has been implicated in a wide array of malignant hematological disorders. There are few reports suggesting its dysregulation in Philadelphia chromosome-negative (Ph) myeloproliferative neoplasms (MPNs). Patients and Methods: We analyzed b-catenin mRNA expression in bone marrow (BM) aspirates of 29 patients with primary (PMF) and 4 patients with secondary, post Ph MPN, myelofibrosis (SMF) using quantitative real-time polymerase chain reaction (qRT PCR). The control group consisted of 16 BM aspirates from patients with limited- stage aggressive non-Hodgkin lymphoma without BM involvement. We compared relative gene expression with clinical and hematological parameters. Results: Relative expression of b- catenin differed significantly among groups (P ¼ .0002), it was significantly higher in patients with PMF and SMF than in the control group, but did not differ between patients with PMF and SMF. A negative correlation was found regarding hemoglobin level in PMF (P ¼ .017). No association according to Janus kinase 2 (JAK2) V617F mutational status or JAK2 V617F allele burden was detected. Conclusion: Our results show for the first time that b-catenin mRNA expression is increased in patients with PMF and SMF and its upregulation might potentiate anemia. A number of inflammatory cytokines associated with PMF are capable of mediating their effects through increased b- catenin expression. Accordingly, b-catenin can induce expression of a number of genes implicated in processes of cell cycle control, fibrosis, and angiogenesis, which are central to the PMF pathogenesis. Therefore, b-catenin might represent an interesting new therapeutic target in these diseases.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinička bolnica "Dubrava"

Citiraj ovu publikaciju

Lucijanić, Marko; Livun, Ana; Tomasović- Lončarić, Čedna; Štoos-Veić, Tajana; Pejša, Vlatko; Jakšić, Ozren; Prka, Željko; Kušec, Rajko
Canonical Wnt/β-Catenin Signaling Pathway Is Dysregulated in Patients With Primary and Secondary Myelofibrosis // Clinical Lymphoma Myeloma & Leukemia, 16 (2016), 9; 523-526 doi:10.1016/j.clml.2016.06.004 (međunarodna recenzija, članak, znanstveni)
Lucijanić, M., Livun, A., Tomasović- Lončarić, Č., Štoos-Veić, T., Pejša, V., Jakšić, O., Prka, Ž. & Kušec, R. (2016) Canonical Wnt/β-Catenin Signaling Pathway Is Dysregulated in Patients With Primary and Secondary Myelofibrosis. Clinical Lymphoma Myeloma & Leukemia, 16 (9), 523-526 doi:10.1016/j.clml.2016.06.004.
@article{article, year = {2016}, pages = {523-526}, DOI = {10.1016/j.clml.2016.06.004}, keywords = {Philadelphia chromosome-negative myeloproliferative neoplasm, anemia, RT PCR, fibrosis, JAK2 V617F}, journal = {Clinical Lymphoma Myeloma and Leukemia}, doi = {10.1016/j.clml.2016.06.004}, volume = {16}, number = {9}, issn = {2152-2650}, title = {Canonical Wnt/β-Catenin Signaling Pathway Is Dysregulated in Patients With Primary and Secondary Myelofibrosis}, keyword = {Philadelphia chromosome-negative myeloproliferative neoplasm, anemia, RT PCR, fibrosis, JAK2 V617F} }
@article{article, year = {2016}, pages = {523-526}, DOI = {10.1016/j.clml.2016.06.004}, keywords = {Philadelphia chromosome-negative myeloproliferative neoplasm, anemia, RT PCR, fibrosis, JAK2 V617F}, journal = {Clinical Lymphoma Myeloma and Leukemia}, doi = {10.1016/j.clml.2016.06.004}, volume = {16}, number = {9}, issn = {2152-2650}, title = {Canonical Wnt/β-Catenin Signaling Pathway Is Dysregulated in Patients With Primary and Secondary Myelofibrosis}, keyword = {Philadelphia chromosome-negative myeloproliferative neoplasm, anemia, RT PCR, fibrosis, JAK2 V617F} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • MEDLINE


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