Facile synthesis and cytotoxic activity of the first ferrocene-resveratrol conjugate (CROSBI ID 232784)
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Kovač, Veronika ; Kmetič, Ivana ; Murati, Teuta ; Miletić, Marina ; Barišić, Lidija
engleski
Facile synthesis and cytotoxic activity of the first ferrocene-resveratrol conjugate
The bioorganometallic III containing trimethylene chain between ferrocene and resveratrol (3, 5, 4'-trihydroxystilbene, RSV) moieties connected via ester bond has been synthesized. The novel bioconjugate was characterized using IR and NMR (1H, 13C, COSY, NOESY, HMBC) spectroscopy, ESI-MS and HRMS. The RSV and ferrocene-RSV conjugate III were screened in vitro for their inhibitory effects against proliferation of hepatoblastoma (Hep G2) cells by MTT assay. Also, possible cytotoxicity towards normal ovary cells (CHO-K1) was evaluated. The obtained data revealed profound effects in biological/cytotoxic activity of III vs. RSV in Hep G2 cell line. Lower cytotoxicity of III was observed in normal ovary cells as compared to hepatoblastoma cells.
Ferrocene ; Ferrocene-resveratrol conjugate ; Hepatoblastoma ; Normal ovary cells ; Resveratrol
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