Novi prediktor smrtnog ishoda u bolesnika s akutnim srčanim zatajivanjem (CROSBI ID 641195)
Prilog sa skupa u časopisu | prošireni sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Radulović, Bojana ; Trbušić, Matias ; Potočnjak, Ines ; Dokoza-Terešak, Sanda ; Vrkić, Nada ; Starčević, Neven ; Milošević, Milan ; Frank, Saša ; Degoricija, Vesna
hrvatski
Novi prediktor smrtnog ishoda u bolesnika s akutnim srčanim zatajivanjem
Introduction: Numerous studies have shown that during heart failure (HF) exacerbation patients with hyponatraemia have higher mortality, longer hospital stay and higher incidence of rehospitalisation due to HF. To date there has not been effective therapy for hyponatriaemia in AHF. Until now, research related to hyponatriaemia in HF patients did not focus on serum chloride levels, mostly due to traditional view of chloride as a secondary electrolyte whose levels are dependent on sodium levels and acid- base balance. The present study investigated the relationship between serum chloride and follow-up sodium levels in acute heart failure (AHF) patients with normal initial sodium level.1 Patients and Methods: The present study was performed as a prospective, single-centre, observational research with a total of 152 hospitalized AHF patients in University Hospital Centre “Sestre milosrdnice”. Patients have been divided in four groups depending on values of sodium and chloride. Patients were monitored on the second, third and seventh day of hospitalisation and follow up was done after three months. We statistically calculated the likelihood of these groups for developing hyponatriaemia after three months and mortality. Results: Compared to patients with initial normochloraemia and normonatriaemia, patients with initial hypochloraemia and normonatriaemia had a statistically signifcant higher incidence of hyponatraemia after a 3- months follow-up. Binary logistic regression revealed a signifcantly increased in-hospital mortality in the hypochloraemic/normonatriaemic group. Interestingly, ejection fraction at admission was the highest in hypochloraemic/normonatriaemic patients, although that group of patients had signifcantly increased in-hospital mortality. The lowest ejection fraction was in a group of patients with hypochloraemic/hyponatraemic patients. The N-terminal precursor Brain Natriuretic Peptide (NT-proBNP) levels at admission were signifcantly lower in hypochloraemic/normonatriaemic compared to other groups. Conclusion: Our study showed that initial low serum chloride concentration is predictive of developing hyponatraemia and associated with increased in-hospital mortality in HF patients. Chloride levels could be used to detect high- risk patients and start appropriate therapy early enough to prevent poor outcome of AHF patients.
heart failure ; hypochloraemia ; mortality
nije evidentirano
engleski
New predictor of mortality in patients with acute heart failure
nije evidentirano
heart failure ; hypochloraemia ; mortality
nije evidentirano
Podaci o prilogu
399-399.
2016.
nije evidentirano
objavljeno
doi.org/10.15836/ccar2016.399
Podaci o matičnoj publikaciji
Cardiologia Croatica
Miličić, Davor
Zagreb: Hrvatsko kardiološko društvo
1848-543X
1848-5448
Podaci o skupu
11. kongres Hrvatskoga kardiološkog društva s međunarodnim sudjelovanjem
poster
03.11.2016-06.11.2016
Zagreb, Hrvatska