engleski

Blocked K antigen of neonatal red blood cells- which is the critical titre?

Blocked erythrocyte antigens, first described in 1944, occured due to potent maternal anti-D antibodies that blocked D antigens on foetal red blood cells(RBCs) causing them to be negative when typing with human immunoglobulin M anti-D. The phenomenon is rare and where it does occur antibody doesn't have to be of high titre. There are only two case reports in literature that describe false negative K phenotyping due to blocking with maternal anti- K, phenomenon registered at a titre level of 128 or greater. We want to present a case report of a potent anti-K antibody which blocked K antigens on neonatal RBCs and made them phenotyped as K negative. Complete blocking of K antigen is not widely described, nor perhaps recognized. Manufacturers product inserts should note this possibility and laboratory staff should also have this situation in mind when performing such tests. We proved blocking effect of anti- K at titre of 32, which is lower than previously reported.

blocked K antigen; potent anti-K antibody

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