engleski

Methicillin-resistant Staphylococcus aureus in North-east Croatia

Objective. The aim of this 5-year study was to determine the frequen- cy and antibiotic susceptibility of methicillin-resistant Staphylococcus aureus ( MRSA)-related infections at Osijek Clinical Hospital. Ma - terials and methods. A total of 1987 staphylococci-infected clinical isolates were collected and analysed at the Microbiology Department of the Public Health Institute of Osijek-Baranja County. Results. Be - tween 2008 and 2012, the average rate of MRSA-related infections in staphylococci-infected patients was 27.4%. The proportion of MRSA- related infections on all Staphylococcus aureus (S. aureus) isolates from clinical specimens showed a decreasing trend, from 32.6% in 2008 to 25.5% in 2012. MRSA-related infections were mostly detected in wound swabs (50.6%) and aspirates (28.8%) of patients hospitalized in the surgical (49.8%) and intensive care units (27.9%). MRSA-relat- ed infection showed an increase compared to S. aureus -infections in samples of wounds and aspirates in 2011 and 2012 (57.9%/34.9% and 35.2%/16.3%, respectively). The majority of strains of MRSA-related infections were resistant to several antibiotics, including erythromycin and clindamycin, where susceptibility were less than 10%. All MRSA isolates were susceptible to vancomycin, teicoplanin and linezolid. Therefore, antibiotic therapies for MRSA infections include vancomy- cin, teicoplanin and linezolid, but microbiological diagnostics need to be performed in order to know when the use of glycopeptides and oxazolidinones is indicated. Conclusion. Our results suggest that ap- propriate prevention measures, combined with the more rational use of antibiotics are crucial to reduce the spread of MRSA-related infec- tion in healthcare settings. Further monitoring is necessary of the in- cidence and antibiotic susceptibility of MRSA-related infections in our community.

Staphylococcus aureus  MRSA  Healthcare-associated infection

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