engleski

Lipid/alginate nanoparticles for dexamethasone nasal delivery

In this work, we present the development of dexamethasone-loaded lipid/alginate nanoparticles that could provide prolonged dexamethasone release and prolonged residence time at the nasal mucosa, ensuring its local effect upon the administration of a lower dose. Prolonged residence time can be expected due to alginate bioadhesive properties, but could further be improved by adjusting alginate concentration in the nanoparticle suspension to the range in which it could form hydrogel in contant with calcium ions present in the nasal mucosa.

alginate; biocompatibility; Lecithin S100; Dimethyldioctadecylammonum bromide

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