engleski

Reduction of Ribonucleotide in Prebiotic Conditions

The prerequisite for creation of the first living organisms on Earth was the existence of a "molecules of life" such as nucleic acids, amino acids and sugars. Model studies of prebiotic chemistry have revealed persuasive routes for the formation of the building blocks of proteins and RNA, but not DNA. Nowadays, the deoxyribonucleotides required for the construction of DNA are formed in reduction of ribonucleotides catalyzed by radical enzymes ribonucleotide reductases. This work considers potential non-enzymatic routes via intermediate radicals for the ancient formation of deoxynucleotides. We will present several computationally modeled mechanisms of ribonucleotide reduction without the presence of enzymes.

ribonucleotides; deoxyribonucleotides; non-enzimatic reduction; DFT; reaction mechanism

nije evidentirano