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Pregled bibliografske jedinice broj: 838204

MITOPHAGY RECEPTORS ARE REGULATED BY PHOSPHORYLATION AND OLIGOMERIZATION


Mija Marinković, Maja Buljubašić, Matilda Šprung, Vladimir Rogov, Anne Hamacher-Brady, Nathan Brady, Volker Dötsch, Ivan Đikić and Ivana Novak
MITOPHAGY RECEPTORS ARE REGULATED BY PHOSPHORYLATION AND OLIGOMERIZATION // Copenhagen Bioscience Conference
Kopenhagen, Danska, 2016. str. 141-142 (poster, nije recenziran, sažetak, znanstveni)


CROSBI ID: 838204 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
MITOPHAGY RECEPTORS ARE REGULATED BY PHOSPHORYLATION AND OLIGOMERIZATION

Autori
Mija Marinković, Maja Buljubašić, Matilda Šprung, Vladimir Rogov, Anne Hamacher-Brady, Nathan Brady, Volker Dötsch, Ivan Đikić and Ivana Novak

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Copenhagen Bioscience Conference / - , 2016, 141-142

Skup
Protein signaling-from pathways to networks

Mjesto i datum
Kopenhagen, Danska, 02.-06.10.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
mitophagy ; phosphorylation

Sažetak
Mitophagy, a selective autophagy process whereby dysfunctional or impaired mitochondria are cleared from the cell, is very important since inability to remove damaged mitochondria could result in their accumulation and subsequently lead to the development of serious diseases such as cancer or neurodegeneration. Our discoveries of mitophagy receptors, Nix and Bnip3, have shown that they interact with Atg8 proteins in LIR-dependent manner and recruit autophagic machinery to damaged mitochondria. Moreover, we have shown that Nix mediates mitochondrial clearance during reticulocyte differentiation. What are the mechanisms that activate mitophagy receptors is still not fully understood but we postulate that, as other autophagy receptors, these are activated by phosphorylation of the serines adjacent to LIR motif. Further, we propose that Nix and Bnip3 could increase activation of mitophagy by their oligomerization. In our current research, we are investigating how oligomerization status of the receptors influences mitophagy initiation and progression and what is the interplay between phosphorylation and oligomerization status of the receptors.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
HRZZ-UIP-2013-11-5246 - Uloga receptora autofagije u selektivnom uklanjanju mitohondrija (AutoMito) (Novak Nakir, Ivana, HRZZ - 2013-11) ( POIROT)

Ustanove:
Medicinski fakultet, Split


Citiraj ovu publikaciju

Mija Marinković, Maja Buljubašić, Matilda Šprung, Vladimir Rogov, Anne Hamacher-Brady, Nathan Brady, Volker Dötsch, Ivan Đikić and Ivana Novak
MITOPHAGY RECEPTORS ARE REGULATED BY PHOSPHORYLATION AND OLIGOMERIZATION // Copenhagen Bioscience Conference
Kopenhagen, Danska, 2016. str. 141-142 (poster, nije recenziran, sažetak, znanstveni)
Mija Marinković, Maja Buljubašić, Matilda Šprung, Vladimir Rogov, Anne Hamacher-Brady, Nathan Brady, Volker Dötsch, Ivan Đikić and Ivana Novak (2016) MITOPHAGY RECEPTORS ARE REGULATED BY PHOSPHORYLATION AND OLIGOMERIZATION. U: Copenhagen Bioscience Conference.
@article{article, year = {2016}, pages = {141-142}, keywords = {mitophagy, phosphorylation}, title = {MITOPHAGY RECEPTORS ARE REGULATED BY PHOSPHORYLATION AND OLIGOMERIZATION}, keyword = {mitophagy, phosphorylation}, publisherplace = {Kopenhagen, Danska} }
@article{article, year = {2016}, pages = {141-142}, keywords = {mitophagy, phosphorylation}, title = {MITOPHAGY RECEPTORS ARE REGULATED BY PHOSPHORYLATION AND OLIGOMERIZATION}, keyword = {mitophagy, phosphorylation}, publisherplace = {Kopenhagen, Danska} }




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