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Pregled bibliografske jedinice broj: 838054

Role of capsaicin-sensitive neurons in bilateral antinociceptive effect of botulinum toxin type A


Drinovac, Višnja; Bach-Rojecky, Lidija; Matak, Ivica; Lacković, Zdravko
Role of capsaicin-sensitive neurons in bilateral antinociceptive effect of botulinum toxin type A // 10th Forum of Neuroscience (FENS 2016)
Kopenhagen, Danska, 2016. (poster, međunarodna recenzija, sažetak, znanstveni)


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Naslov
Role of capsaicin-sensitive neurons in bilateral antinociceptive effect of botulinum toxin type A

Autori
Drinovac, Višnja ; Bach-Rojecky, Lidija ; Matak, Ivica ; Lacković, Zdravko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
10th Forum of Neuroscience (FENS 2016)

Mjesto i datum
Kopenhagen, Danska, 2.-6. 07. 2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Botulinum toxin A; Mirror pain; Capsaicin-sensitive neurons

Sažetak
Background and aims: Recently is suggested that botulinum toxin A (BTX-A) requires axonal transport from periphery to central nervous system through capsaicin-sensitive neurons to achieve specific antihyperalgesic and antiallodynic effect. The aim of this study was to investigate the effect of sciatic nerve capsaicin-sensitive fibers desensitization on, previously demonstrated, bilateral antinociceptive effect in a model of “mirror pain” induced by intramuscular carrageenan injection. Methods: 100μL 3% carrageenan (dissolved in saline) or saline was injected into right gastrocnemius muscle of male Wistar rats. Animals which developed bilateral mechanical allodynia two weeks following carrageenan injection were divided into following groups (5-6 animals per experimental group): (1) and (2) saline or BTX (5U/kg) intraplantar (subcutaneously into the right hind-paw pad), (3) and (4) vehiculum or capsaicin perisciatic (15 min ; right sciatic nerve), (5) and (6) BTX-A + capsaicin or vehiculum perisciatic. Nociceptive measurements were performed using von Frey filaments. Results: Unilateral BTX-A decreased mechanical hypersensitivity not only on ipsilateral (p<0.05), but on the contralateral side as well (p<0.05). In contrast, ipsilateral perineural capsaicin decreased mechanical hypersenitivity only at the side of pain induction (p<0.01). In combination with BTX-A, we observed no additive or synergistic ipsilateral effects. Ipsilateral capsaicin did not affect contralateral BTX-A's effect. Conclusions: Presented results support recent findings that central antinociceptive effect of BTX-A might be associated with the activity of capsaicin-sensitive neurons in the area of sciatic innervation, since capsaicin and BTX-A had no additive/synergistic antinociceptive effects. In addition, it distinguishes the bilateral versus unilateral effects of peripherally applied BTX-A and capsaicin which might be important in further understanding of “mirror pain” origin, as well as potential transcytosis of BTX-A in spinal circuits.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-4503 - Klostridijski neurotoksini i mozak (BrainTox) (Lackovic, Zdravko, HRZZ - 2014-09) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju

Drinovac, Višnja; Bach-Rojecky, Lidija; Matak, Ivica; Lacković, Zdravko
Role of capsaicin-sensitive neurons in bilateral antinociceptive effect of botulinum toxin type A // 10th Forum of Neuroscience (FENS 2016)
Kopenhagen, Danska, 2016. (poster, međunarodna recenzija, sažetak, znanstveni)
Drinovac, V., Bach-Rojecky, L., Matak, I. & Lacković, Z. (2016) Role of capsaicin-sensitive neurons in bilateral antinociceptive effect of botulinum toxin type A. U: 10th Forum of Neuroscience (FENS 2016).
@article{article, year = {2016}, keywords = {Botulinum toxin A, Mirror pain, Capsaicin-sensitive neurons}, title = {Role of capsaicin-sensitive neurons in bilateral antinociceptive effect of botulinum toxin type A}, keyword = {Botulinum toxin A, Mirror pain, Capsaicin-sensitive neurons}, publisherplace = {Kopenhagen, Danska} }
@article{article, year = {2016}, keywords = {Botulinum toxin A, Mirror pain, Capsaicin-sensitive neurons}, title = {Role of capsaicin-sensitive neurons in bilateral antinociceptive effect of botulinum toxin type A}, keyword = {Botulinum toxin A, Mirror pain, Capsaicin-sensitive neurons}, publisherplace = {Kopenhagen, Danska} }




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