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Pregled bibliografske jedinice broj: 838018

Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain


Drinovac, Višnja; Bach-Rojecky, Lidija; Lacković, Zdravko
Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain // Journal of neural transmission (2016) (znanstveni, prihvaćen)


CROSBI ID: 838018 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain

Autori
Drinovac, Višnja ; Bach-Rojecky, Lidija ; Lacković, Zdravko

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Journal of neural transmission (2016)

Status rada
Prihvaćen

Ključne riječi
Botulinum toxin A ; Capsaicin-sensitive neurons ; Cleaved SNAP-25 ; GABAA antagonist ; Mirror pain ; μ-opioid antagonist

Sažetak
“Mirror pain” or mirror-image pain (MP) is pain opposite to the side of injury. Mechanism and frequency in humans are not known. There is no consent on therapy. Here we report that unilaterally injected botulinum toxin type A (BT-A) has bilateral effect in experimental MP, thus deserves to be investigated as therapy for this condition. We examined the localization of BT-A’s bilateral antinociceptive action in MP induced by 3 % carrageenan intramuscular injection in Wistar rats. BT-A was applied peripherally (5 U/kg), into ipsilateral or contralateral hind paw pad (i.pl.) and centrally (1 U/kg), at spinal (intrathecally, i.t.) or supraspinal (intracisternally, i.c.) level. Additionally, we examined the involvement of central opioid and GABAergic systems, as well as the contribution of peripheral capsaicin-sensitive neurons to BT-A’s bilateral antinociceptive effect. Ipsilateral i.pl. and i.t. BT-A reduced the bilateral mechanical sensitivity to von Frey filaments, while contralateral i.pl. and i.c. treatments had no effect on either tested side. Bilateral antinociceptive effect of ipsilateral i.pl. BT-A was prevented by μ-opioid antagonist naloxonazine (1.5 μg/10 μl) and GABAA antagonist bicuculline (1 μg/10 μl) if applied at the spinal level, in contrast to supraspinal application of the same doses. Local treatment of sciatic nerve with 2 % capsaicin 5 days following BT-A i.pl. injection caused desensitization of sciatic capsaicin-sensitive fibers, but did not affect bilateral antinociceptive effect of BT-A and the presence of cleaved SNAP-25 at the spinal cord slices. Present experiments suggest segmental actions of peripheral BT-A at spinal level, which are probably not solely dependent on capsaicin-sensitive neurons

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-4503 - Klostridijski neurotoksini i mozak (BrainTox) (Lackovic, Zdravko, HRZZ - 2014-09) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju

Drinovac, Višnja; Bach-Rojecky, Lidija; Lacković, Zdravko
Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain // Journal of neural transmission (2016) (znanstveni, prihvaćen)
Drinovac, V., Bach-Rojecky, L. & Lacković, Z. (2016) Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain. Prihvaćen za objavljivanje u Journal of neural transmission. [Preprint].
@unknown{unknown, year = {2016}, keywords = {Botulinum toxin A, Capsaicin-sensitive neurons, Cleaved SNAP-25, GABAA antagonist, Mirror pain, μ-opioid antagonist}, journal = {Journal of neural transmission}, title = {Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain}, keyword = {Botulinum toxin A, Capsaicin-sensitive neurons, Cleaved SNAP-25, GABAA antagonist, Mirror pain, μ-opioid antagonist} }
@unknown{unknown, year = {2016}, keywords = {Botulinum toxin A, Capsaicin-sensitive neurons, Cleaved SNAP-25, GABAA antagonist, Mirror pain, μ-opioid antagonist}, journal = {Journal of neural transmission}, title = {Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain}, keyword = {Botulinum toxin A, Capsaicin-sensitive neurons, Cleaved SNAP-25, GABAA antagonist, Mirror pain, μ-opioid antagonist} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
  • Scopus
  • MEDLINE





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