Naslov
Multicomponent synthesis of hydrazino depsipeptides

Autori
Suć, Josipa ; Barić, Danijela ; Jerić, Ivanka

Izvornik
RSC Advances (2046-2069) 6 (2016), 102; 99664-99675

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Multicomponent reactions ; Passerini reaction ; hydrazino acids ; depsipeptides ; peptidomimetics

Sažetak
The Passerini reaction ofalpha-hydrazino acids, carbonyl compounds and isocyanides yielded hydrazino depsipeptides, a new class of backbone extended peptidomimetics comprising amide bond isoster. A wide range of carbonyl and isocyano components were used along the alpha-hydrazino acids carrying three different N alpha protecting groups. The kinetics and thermodynamic equilibrium of the rate-determining step of the reaction with different alpha-hydrazino acids were studied by DFT approach.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA