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Multicomponent synthesis of hydrazino depsipeptides


Suć, Josipa; Barić, Danijela; Jerić, Ivanka
Multicomponent synthesis of hydrazino depsipeptides // RSC Advances, 6 (2016), 102; 99664-99675 doi:10.1039/c6ra23317a (međunarodna recenzija, članak, znanstveni)


Naslov
Multicomponent synthesis of hydrazino depsipeptides

Autori
Suć, Josipa ; Barić, Danijela ; Jerić, Ivanka

Izvornik
RSC Advances (2046-2069) 6 (2016), 102; 99664-99675

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Multicomponent reactions ; Passerini reaction ; hydrazino acids ; depsipeptides ; peptidomimetics

Sažetak
The Passerini reaction ofalpha-hydrazino acids, carbonyl compounds and isocyanides yielded hydrazino depsipeptides, a new class of backbone extended peptidomimetics comprising amide bond isoster. A wide range of carbonyl and isocyano components were used along the alpha-hydrazino acids carrying three different N alpha protecting groups. The kinetics and thermodynamic equilibrium of the rate-determining step of the reaction with different alpha-hydrazino acids were studied by DFT approach.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2014-09-3102 - Višekomponentne reakcije u sintezi peptidnih mimetika (IVANKA JERIĆ, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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