Multicomponent synthesis of hydrazino depsipeptides (CROSBI ID 231982)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Suć, Josipa ; Barić, Danijela ; Jerić, Ivanka
engleski
Multicomponent synthesis of hydrazino depsipeptides
The Passerini reaction ofalpha-hydrazino acids, carbonyl compounds and isocyanides yielded hydrazino depsipeptides, a new class of backbone extended peptidomimetics comprising amide bond isoster. A wide range of carbonyl and isocyano components were used along the alpha-hydrazino acids carrying three different N alpha protecting groups. The kinetics and thermodynamic equilibrium of the rate-determining step of the reaction with different alpha-hydrazino acids were studied by DFT approach.
multicomponent reactions ; Passerini reaction ; hydrazino acids ; depsipeptides ; peptidomimetics
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