Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin (CROSBI ID 231824)

Prilog u časopisu | ispravak

Bix, Gregory ; Fu, Jian ; Gonzalez, Eva M. ; Macro, Laura ; Barker, Amy ; Campbell, Shelly ; Zutter, Mary M. ; Santoro, Samuel A. ; Kim, Jiyeun K. ; Höök, Magnus et al. Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin // The Journal of cell biology, 201 (2013), 4; 641-641. doi: 10.1083/jcb.20040115004252013c

Podaci o odgovornosti

Bix, Gregory ; Fu, Jian ; Gonzalez, Eva M. ; Macro, Laura ; Barker, Amy ; Campbell, Shelly ; Zutter, Mary M. ; Santoro, Samuel A. ; Kim, Jiyeun K. ; Höök, Magnus ; Reed, Charles C. ; Iozzo, Renato V.

engleski

Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin

Endorepellin, the COOH-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits several aspects of angiogenesis. We provide evidence for a novel biological axis that links a soluble fragment of perlecan protein core to the major cell surface receptor for collagen I, α2β1 integrin, and provide an initial investigation of the intracellular signaling events that lead to endorepellin antiangiogenic activity. The interaction between endorepellin and α2β1 integrin triggers a unique signaling pathway that causes an increase in the second messenger cAMP ; activation of two proximal kinases, protein kinase A and focal adhesion kinase ; transient activation of p38 mitogen-activated protein kinase and heat shock protein 27, followed by a rapid down-regulation of the latter two proteins ; and ultimately disassembly of actin stress fibers and focal adhesions. The end result is a profound block of endothelial cell migration and angiogenesis. Because perlecan is present in both endothelial and smooth muscle cell basement membranes, proteolytic activity during the initial stages of angiogenesis could liberate antiangiogenic fragments from blood vessels' walls, including endorepellin.

perlecan proteoglycan ; angiogenesis ; endothelial cell ; collagen ; LG module

This corrects the article "Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin" in volume 166 on page 97.

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

201 (4)

2013.

641-641

objavljeno

0021-9525

10.1083/jcb.20040115004252013c

Povezanost rada

Povezane osobe



Biologija

Poveznice
Indeksiranost