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Pregled bibliografske jedinice broj: 836819

Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin


Bix, Gregory; Fu, Jian; Gonzalez, Eva M.; Macro, Laura; Barker, Amy; Campbell, Shelly; Zutter, Mary M.; Santoro, Samuel A.; Kim, Jiyeun K.; Höök, Magnus et al.
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin // The Journal of cell biology, 201 (2013), 4; 641-641 doi:10.1083/jcb.20040115004252013c (podatak o recenziji nije dostupan, ispravak, znanstveni)


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Naslov
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin

Autori
Bix, Gregory ; Fu, Jian ; Gonzalez, Eva M. ; Macro, Laura ; Barker, Amy ; Campbell, Shelly ; Zutter, Mary M. ; Santoro, Samuel A. ; Kim, Jiyeun K. ; Höök, Magnus ; Reed, Charles C. ; Iozzo, Renato V.

Izvornik
The Journal of cell biology (0021-9525) 201 (2013), 4; 641-641

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, ispravak, znanstveni

Ključne riječi
perlecan proteoglycan ; angiogenesis ; endothelial cell ; collagen ; LG module

Sažetak
Endorepellin, the COOH-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits several aspects of angiogenesis. We provide evidence for a novel biological axis that links a soluble fragment of perlecan protein core to the major cell surface receptor for collagen I, α2β1 integrin, and provide an initial investigation of the intracellular signaling events that lead to endorepellin antiangiogenic activity. The interaction between endorepellin and α2β1 integrin triggers a unique signaling pathway that causes an increase in the second messenger cAMP ; activation of two proximal kinases, protein kinase A and focal adhesion kinase ; transient activation of p38 mitogen-activated protein kinase and heat shock protein 27, followed by a rapid down-regulation of the latter two proteins ; and ultimately disassembly of actin stress fibers and focal adhesions. The end result is a profound block of endothelial cell migration and angiogenesis. Because perlecan is present in both endothelial and smooth muscle cell basement membranes, proteolytic activity during the initial stages of angiogenesis could liberate antiangiogenic fragments from blood vessels' walls, including endorepellin.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

Napomena
This corrects the article "Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin" in volume 166 on page 97.



POVEZANOST RADA


Profili:

Avatar Url Shelly Pranić (autor)

Citiraj ovu publikaciju

Bix, Gregory; Fu, Jian; Gonzalez, Eva M.; Macro, Laura; Barker, Amy; Campbell, Shelly; Zutter, Mary M.; Santoro, Samuel A.; Kim, Jiyeun K.; Höök, Magnus et al.
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin // The Journal of cell biology, 201 (2013), 4; 641-641 doi:10.1083/jcb.20040115004252013c (podatak o recenziji nije dostupan, ispravak, znanstveni)
Bix, G., Fu, J., Gonzalez, E., Macro, L., Barker, A., Campbell, S., Zutter, M., Santoro, S., Kim, J. & Höök, M. (2013) Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin. The Journal of cell biology, 201 (4), 641-641 doi:10.1083/jcb.20040115004252013c.
@article{article, year = {2013}, pages = {641-641}, DOI = {10.1083/jcb.20040115004252013c}, keywords = {perlecan proteoglycan, angiogenesis, endothelial cell, collagen, LG module}, journal = {The Journal of cell biology}, doi = {10.1083/jcb.20040115004252013c}, volume = {201}, number = {4}, issn = {0021-9525}, title = {Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin}, keyword = {perlecan proteoglycan, angiogenesis, endothelial cell, collagen, LG module} }
@article{article, year = {2013}, pages = {641-641}, DOI = {10.1083/jcb.20040115004252013c}, keywords = {perlecan proteoglycan, angiogenesis, endothelial cell, collagen, LG module}, journal = {The Journal of cell biology}, doi = {10.1083/jcb.20040115004252013c}, volume = {201}, number = {4}, issn = {0021-9525}, title = {Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin}, keyword = {perlecan proteoglycan, angiogenesis, endothelial cell, collagen, LG module} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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