Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin (CROSBI ID 231824)
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Podaci o odgovornosti
Bix, Gregory ; Fu, Jian ; Gonzalez, Eva M. ; Macro, Laura ; Barker, Amy ; Campbell, Shelly ; Zutter, Mary M. ; Santoro, Samuel A. ; Kim, Jiyeun K. ; Höök, Magnus ; Reed, Charles C. ; Iozzo, Renato V.
engleski
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin
Endorepellin, the COOH-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits several aspects of angiogenesis. We provide evidence for a novel biological axis that links a soluble fragment of perlecan protein core to the major cell surface receptor for collagen I, α2β1 integrin, and provide an initial investigation of the intracellular signaling events that lead to endorepellin antiangiogenic activity. The interaction between endorepellin and α2β1 integrin triggers a unique signaling pathway that causes an increase in the second messenger cAMP ; activation of two proximal kinases, protein kinase A and focal adhesion kinase ; transient activation of p38 mitogen-activated protein kinase and heat shock protein 27, followed by a rapid down-regulation of the latter two proteins ; and ultimately disassembly of actin stress fibers and focal adhesions. The end result is a profound block of endothelial cell migration and angiogenesis. Because perlecan is present in both endothelial and smooth muscle cell basement membranes, proteolytic activity during the initial stages of angiogenesis could liberate antiangiogenic fragments from blood vessels' walls, including endorepellin.
perlecan proteoglycan ; angiogenesis ; endothelial cell ; collagen ; LG module
This corrects the article "Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through α2β1 integrin" in volume 166 on page 97.
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Podaci o izdanju
201 (4)
2013.
641-641
objavljeno
0021-9525
10.1083/jcb.20040115004252013c