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Pregled bibliografske jedinice broj: 835194

Platelet serotonin concentration and depressive symptoms in patients with schizophrenia


Peitl, Vjekoslav; Vidrih, Branka; Karlović, Zoran; Getaldić, Biserka; Peitl, Milena; Karlović, Dalibor
Platelet serotonin concentration and depressive symptoms in patients with schizophrenia // Psychiatry research, 239 (2016), 105-110 doi:10.1016/j.psychres.2016.03.006 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 835194 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Platelet serotonin concentration and depressive symptoms in patients with schizophrenia

Autori
Peitl, Vjekoslav ; Vidrih, Branka ; Karlović, Zoran ; Getaldić, Biserka ; Peitl, Milena ; Karlović, Dalibor

Izvornik
Psychiatry research (0165-1781) 239 (2016); 105-110

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Blood platelets ; Depression ; Psychiatric status rating scales ; Schizophrenia ; Serotonin

Sažetak
Depressive symptoms seem to be frequent in schizophrenia, but so far they have received less attention than other symptom domains. Impaired serotonergic neurotransmission has been implicated in the pathogenesis of depression and schizophrenia. The objectives of this study were to investigate platelet serotonin concentrations in schizophrenic patients with and without depressive symptoms, and to investigate the association between platelet serotonin concentrations and symptoms of schizophrenia, mostly depressive symptoms. A total of 364 patients were included in the study, 237 of which had significant depressive symptoms. Significant depressive symptoms were defined by the cut-off score of 7 or more on Calgary Depression Rating Scale (CDSS). Platelet serotonin concentrations were assessed by the enzyme-linked immunosorbent assay (ELISA). Prevalence of depression in patients with schizophrenia was 65.1%. Schizophrenic patients with depressive symptoms showed lower platelet serotonin concentrations (mean±SD ; 490.6±401.2) compared to schizophrenic patients without depressive symptoms (mean±SD ; 660.9±471.5). An inverse correlation was established between platelet serotonin concentration and depressive symptoms, with more severe symptoms being associated with lower platelet serotonin concentrations. Depressive symptoms in schizophrenic patients may be associated with reduced concentrations of platelet serotonin.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Stomatološki fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Katolički bogoslovni fakultet, Zagreb

Citiraj ovu publikaciju

Peitl, Vjekoslav; Vidrih, Branka; Karlović, Zoran; Getaldić, Biserka; Peitl, Milena; Karlović, Dalibor
Platelet serotonin concentration and depressive symptoms in patients with schizophrenia // Psychiatry research, 239 (2016), 105-110 doi:10.1016/j.psychres.2016.03.006 (međunarodna recenzija, članak, znanstveni)
Peitl, V., Vidrih, B., Karlović, Z., Getaldić, B., Peitl, M. & Karlović, D. (2016) Platelet serotonin concentration and depressive symptoms in patients with schizophrenia. Psychiatry research, 239, 105-110 doi:10.1016/j.psychres.2016.03.006.
@article{article, year = {2016}, pages = {105-110}, DOI = {10.1016/j.psychres.2016.03.006}, keywords = {Blood platelets, Depression, Psychiatric status rating scales, Schizophrenia, Serotonin}, journal = {Psychiatry research}, doi = {10.1016/j.psychres.2016.03.006}, volume = {239}, issn = {0165-1781}, title = {Platelet serotonin concentration and depressive symptoms in patients with schizophrenia}, keyword = {Blood platelets, Depression, Psychiatric status rating scales, Schizophrenia, Serotonin} }
@article{article, year = {2016}, pages = {105-110}, DOI = {10.1016/j.psychres.2016.03.006}, keywords = {Blood platelets, Depression, Psychiatric status rating scales, Schizophrenia, Serotonin}, journal = {Psychiatry research}, doi = {10.1016/j.psychres.2016.03.006}, volume = {239}, issn = {0165-1781}, title = {Platelet serotonin concentration and depressive symptoms in patients with schizophrenia}, keyword = {Blood platelets, Depression, Psychiatric status rating scales, Schizophrenia, Serotonin} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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