engleski

Antioxidant and anticholinesterase potential of Centaurea rupestris volatile oil from Croatia

Centaurea genus, Asteracea family, is widespread in worldwide area comprising around 400 up to 700 species, of which around 80 with 27 endemics are present in Croatia. Centaurea species are well known for their medicinal properties as result of many bioactive compounds they comprise. In eastern Mediterranean ethnopharmacology they are used as medical plants in treatment of diseases like peptic ulcer, herpes labialis, malaria, common cold, abscesses, hemorrhoids, dyspepsia and some gastrointestinal disorders. Good biological activity of Centaurea essential oils is usually connected with the dominant compounds present in essential oils. Aim of this work was to characterize the essential oil composition as well as antioxidant and anticholinesterase activity of Centaurea rupestris from Croatia. Essential oils were hydrodistilled from aerial parts of the plants in Clevenger-like apparatus while chemical composition of oil was assessed using gas chromatography/mass spectrometry technique (GC/MS). The antioxidant potential was tested by DPPH and FRAP method while anticholinesterase potential was tested by Ellman method. The main constituents present in isolated oil were germacrene D (24.3%), heptacosane (14.4%), phytol (6.7%) and β-caryophyllene (5.0%). All listed compound are common constituents of Centaurea essential oils. Antioxidant potential was no showed promising effect unlike anticholinesterase potential.

Centaurea rupestris ; essential oil ; GC/MS ; antioxidant and anticholinesterase potential

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