Radioprotective effect of a new synthetised adamantyl-thienylcydine (CROSBI ID 483831)
Prilog sa skupa u zborniku | izvorni znanstveni rad
Podaci o odgovornosti
Ferle-Vidović, Ana ; Jukić, I. ; Škare, D. ; Katušin, J.
engleski
Radioprotective effect of a new synthetised adamantyl-thienylcydine
Several adamantyl derivatives of tenocyclidine,1-[1(2-thienylcyclohexyl)]piperidine (TCP), were synthetised and characterised (Ad-TCP I-IV).Their biological activity was evaluated by in vitro testing of their effect on proliferative and reproductive ability of human tumor strain and non- malignant mouse fibroblasts in culture.These effects were compared with those of tenocyclidine (TCP).We also tested them on cultured cells,for their radioprotective effect after ionising irradiation. The results with non-malignant mouse fibroblasts and human tumour cells show that the piperidine derivative of adamantyl tenocyclidine (Ad-TCP II)has rather outstanding radioprotective properties.This derivative revealed significant radioprotection at all survival levels,depending on the malignant or non-malignant origin of the cells,and it was significantly more evident on mouse fibroblasts then on human tumor cells.These effects were compared with those of tenocyclidine. Introduction Materials and methods
adamantyl derivates
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Podaci o prilogu
2001.
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
IRPA Regional Congress on Radiation Protection in Central Europe
poster
20.05.2001-25.05.2001
Dubrovnik, Hrvatska