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Pregled bibliografske jedinice broj: 834206

Antiproliferative activity of amino substituted benzo[b]thieno[2, 3-b]pyrido[1, 2-a]benzimidazoles explored by 2D and 3D cell culture system


Perin, Nataša; Bobanović, Kristina; Zlatar, Ivo; Jelić, Dubravko; Kelava, Vanja; Koštrun, Sanja; Gabelica Marković, Vesna; Brajša, Karmen; Hranjec, Marijana
Antiproliferative activity of amino substituted benzo[b]thieno[2, 3-b]pyrido[1, 2-a]benzimidazoles explored by 2D and 3D cell culture system // European journal of medicinal chemistry, 125 (2017), 722-735 doi:10.1016/j.ejmech.2016.09.084 (međunarodna recenzija, članak, znanstveni)


Naslov
Antiproliferative activity of amino substituted benzo[b]thieno[2, 3-b]pyrido[1, 2-a]benzimidazoles explored by 2D and 3D cell culture system

Autori
Perin, Nataša ; Bobanović, Kristina ; Zlatar, Ivo ; Jelić, Dubravko ; Kelava, Vanja ; Koštrun, Sanja ; Gabelica Marković, Vesna ; Brajša, Karmen ; Hranjec, Marijana

Izvornik
European journal of medicinal chemistry (0223-5234) 125 (2017); 722-735

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antiproliferative activity ; benzo[b]thieno[2 ; 3-b]pyrido[1 ; 2-a]benzimidazoles ; 2D and 3D in vitro cytotoxicity assay ; lipophilicity ; physico-chemical properties

Sažetak
Benzimidazo[1, 2-a]quinolines and benzo[b]thieno[2, 3-b]pyrido[1, 2-a]benzimidazoles with amino chains on the different positions have been evaluated by 2D and 3D assays on the human breast cancer cells. Pentacyclic derivatives were synthesized by microwave assisted amination to study the influence of the thiophene substructure on antitumor activity in comparison to tetracyclic analogues. The results obtained from 2D assay reveals that the antitumor activity is strongly dependent on the nature and position of amino chains. Tetracyclic derivatives displayed selective activity on SK-BR-3 with the 2-amino substituted derivatives as the most active ones while pentacyclic derivatives 6-16 and 21-25 showed more pronounced activity on T47-D . The evaluation of antitumor activity in the 3D assay pointed out that some of the tetracyclic and pentacyclic amino substituted derivatives showed selective activity on the MDA-MB-231 cell line. Influence of physico-chemical properties of the compounds on antiproliferative activity have been investigated by multivariate statistical methods. As a measure of lipophilicity, experimental Chrom LogD values have been determined and number of structural parameters have been calculated for investigated compounds. Main factors contributing to the antiproliferative effect for both 2D and 3D cell cultures are found to be basicity, lipophilicity, molecular weight and number of H-bond donors.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-5596 - SINTEZA I CITOSTATSKA ISPITIVANJA BIBLIOTEKE NOVIH DUŠIKOVIH HETEROCIKLA (Silvana Raić-Malić, )

Ustanove
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Fidelta d.o.o.

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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