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ANTIFUNGAL AND ANTIAFLATOXIGENIC ACTIVITY OF COUMARIN DERIVATIVES


Tomić, Marinko; Buljubašić, Martin; Kovač, Tihomir; Šarkanj, Bojan; Kovač, Marija; Nevistić, Ante; Pavić, Valentina; Strelec, Ivica; Molnar, Maja
ANTIFUNGAL AND ANTIAFLATOXIGENIC ACTIVITY OF COUMARIN DERIVATIVES // Book of abstracts International conference 16th Ružička days “TODAY SCIENCE – TOMMOROW INDUSTRY” / Jukić, Ante (ur.).
Zagreb: Croatian Society of Chemical Engineers ; Faculty of Food Technology Osijek ; Josip Juraj University in Osijek, 2016. str. 66-66 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
ANTIFUNGAL AND ANTIAFLATOXIGENIC ACTIVITY OF COUMARIN DERIVATIVES
(ANTIFUNGALNI I ANTIAFLATOKSIKOGENI UČINAK DERIVATA KUMARINA)

Autori
Tomić, Marinko ; Buljubašić, Martin ; Kovač, Tihomir ; Šarkanj, Bojan ; Kovač, Marija ; Nevistić, Ante ; Pavić, Valentina ; Strelec, Ivica ; Molnar, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts International conference 16th Ružička days “TODAY SCIENCE – TOMMOROW INDUSTRY” / Jukić, Ante - Zagreb : Croatian Society of Chemical Engineers ; Faculty of Food Technology Osijek ; Josip Juraj University in Osijek, 2016, 66-66

ISBN
978-953-7005-40-5

Skup
International conference 16th Ružička days “TODAY SCIENCE – TOMMOROW INDUSTRY”

Mjesto i datum
Vukovar, Croatia, 21-23.09.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Antiaflatoxigenic activity ; antifungal activity ; Aspergillus flavus NRRL 3251 ; coumarin derivatives
(Antiaflatoksikogeno djelovanje ; antifungalno djelovanje ; Aspergillus flavus NRRL 3251 ; derivati kumarina)

Sažetak
Antifungal and antiaflatoxigenic effect of two series of coumarinyl thiosemicarbazides on Aspergillus flavus NRRL 3251 were studied. Fungi were grown in YES medium for 72 h at 29 °C in the presence of 0, 0.1, 1 and 10 µg mL-1 coumarinyl thiosemicarbazides, one series of compounds with substitution in position 7 of coumarin core and another with substitution in position 4 of coumarin core. Dry mycelia weight determination was used for antifungal activity estimation, while aflatoxin B1 content in YES media, determined by dilute and shoot LC-MS/MS technique, was used for antiaflatoxigenic effect estimation. Standard biochemical assays were used for oxidative status markers (TBARS, SOD, CAT and GPX) determination in A. flavus NRRL 3251 mycelia. Results showed that 7- substituted-coumarinyl thiosemicarbazides has better antifungal and antiaflatoxigenic activity than 4-substituted-ones. Among tested, the most prominent was compound 3, N-(4- chlorophenyl)-2-(2-((4-methyl-2-oxo-2H-chromen- 7-yl)oxy)acetyl)hydrazine-1-carbothioamide, which completely inhibited aflatoxin production at concentration of 10 µg mL-1. Oxidative stress response of A. flavus exposed to selected compounds, indicate modulation of oxidative stress as possible reason of aflatoxin production inhibition.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biotehnologija



POVEZANOST RADA


Ustanove
Prehrambeno-tehnološki fakultet, Osijek