engleski

Bone Mineral Density in Relation to Componenets of Metabolic Syndrome in Postmenopausal Women with Diabetes Type 2

Diabetes type 2 is associated with greater bone mineral density (BMD) due to obesity although observed rapid bone loss over time could be explained with elevated chronic inflammation. The objective of this study was to investigate the relationship between central adiposity and hyperinsulinaemia as well as inflammation markers with vertebral and femoral BMD and bone turnover markers in postmenopausal women with type 2 diabetes. Femoral and vertebral BMD, osteocalcin, pyrilinks D, beta-CrossLaps (B-CTx), insulin, CRP, fibrinogen and plasminogen activator inhibitor-1 (PAI-1) were measured in 114 female postmenopausal patients with diabetes type 2. The patients similar in age, HbA1c levels and diabetes duration were divided in 2 groups based on their body mass index (BMI) values: lower or equal to 27 (31 patients) and higher than 27 kg/m2 (83 patients). Lower levels of osteocalcin, B-CTx and pyrilinks D compared to higher femoral BMD as well as insulin, PAI-1 and CRP were found in the overweight group. There were no significant differences in the vertebral BMD, pyrilinks D or fibrinogen. Osteocalcin and B-CTx were inversely correlated, while femoral BMD positively correlated with waist circumference, insulin levels and PAI-1. This suggests that components of the metabolic syndrome, abdominal obesity and hyperinsulinaemia could increase femoral BMD by lowering bone rate. In addition, the only inflammation marker linked with femoral BMD was PAI-1, which is associated with increased mineralization of cortical bone in mouse models.

diabetes type 2 ; adiposity ; hyperinsulinaemia ; inflammation markers ; bone mineral density ; menopause

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