engleski

New topical treatment of symptomatic internal hemorrhoids in a general practice setting

Introduction: Oral usage of flavonoid-based drugs can be successfully applied in the conservative treatment of internal hemorrhoids ; however, its efficiency in a form of topical preparations has not been demonstrated yet. The aim of the present study was to determine the efficiency of ointment with propolis extract (containing minimally 115 mg/kg of flavonoid galangin) in relief and suppression of the symptomatic internal hemorrhoids grade 1 and 2 (bleeding, prolapse, pain, and itching). Methods: This prospective cohort epidemiological study that included 46 participants of both genders, mean age 53.6±14.3 years, was conducted in the general practice setting in Osijek, Croatia and lasted for three months. A specially designed questionnaire was used to collect demographic data and data concerning the hemorrhoid disease symptoms and to evaluate the intensity of the latter data according to the scale defined in the research protocol. Results: The study showed statistically significant improvements in the intensity of all the symptoms connected with the internal hemorrhoids grade 1 and 2 (p<0.001) during the follow up period, as well as statistically significant differences in proportions of participants with and without of the each of the analyzed symptoms before and after the therapy (p<0.001). After three months of therapy with ointment containing propolis extract 82.7% patients (38/46) had none of the analyzed symptoms. Discussion/Conclusions: Ointment with propolis extract efficiently affected all the analyzed symptoms of the hemorrhoid disease thus having a very significant place within the conservative treatment of hemorrhoids.

hemorrhoids ; topical treatment ; propolis ; flavonoid ; Croatia

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