engleski

ACUTE INFLAMMATORY DEMYELINATING POLYNEUROPATHY ASSOCIATED WITH INFLUENZA A INFECTION: CASE REPORT

Introduction/Objectives: Guillain-Barre syndrome (GBS) is an acute monophasic immune mediated disease of the peripheral nervous system that usually occurs after diseases of the digestive or respiratory system. It can occur after influenza or rarely after vaccination against influenza. The spectrum of GBS includes acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor sensory axonal neuropathy (AMSAN), and some other variant like Miller-Fisher syndrome (MFS). Participants, Materials/Methods: Patient with AIDP variant of GBS after severe bilateral pneumonia and ARDS due the influenza A virus is presented. Case report: 57-year-old female was admitted to County General Hospital Požega, Department of Internal Medicine, because of severe ARDS due to bilateral pneumonia during influenza epidemic. After two days she was transmitted to the Intensive Care Unit and than to the Department of Neurology. The course of the disease was complicated with the onset of quadriplegia caused by AIDP variant of GBS. She was treated with intravenous immunoglobulin (IVIG) 0.4 g/kg/day for five days and she completed the physical therapy treatment. Two years after the onset of the disease, motor deficit of all the limbs recovered to the level of paralysis 4-5/5 degree. Conclusions: We reported a case of AIDP variant of GBS associated with proven influenza A infection. Once the diagnosis of GBS is suspected or established, the treatment with intravenous immuneglobulin or plasma exchange (PE) is indicated.

Guillain-Barre syndrome

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