THE BURDEN OF ACUTE ROTAVIRUS GASTROENTERITIS IN CROATIAN CHILDREN – A MULTICENTER PROSPECTIVE STUDY ON CLINICAL CHARACTERISTICS AND MOLECULAR EPIDEMIOLOGY (2012 – 2014). (CROSBI ID 638858)
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Podaci o odgovornosti
• Vrdoljak M, Papić N, Gužvinec M, Butić I, Payer-Pal M, Hegeduš-Jungvirth, Marija ; Tonkić, Marija ; Krželj, Vjekoslav ; Ivić, Ivo ; Tešović, Goran
engleski
THE BURDEN OF ACUTE ROTAVIRUS GASTROENTERITIS IN CROATIAN CHILDREN – A MULTICENTER PROSPECTIVE STUDY ON CLINICAL CHARACTERISTICS AND MOLECULAR EPIDEMIOLOGY (2012 – 2014).
Background Rotavirus (RV) infection is the major cause of infectious diarrhoea in children under age 5. The aim of the study was to determine the epidemiology, seasonality, disease severity and genotype distribution of RV strains causing young children's acute gastroenteritis (AGE) in Croatia. RV vaccine is not a part of NIP in Croatia. Methods 1571 children with all-cause AGE, aged less than 5 years, were included in this prospective multicentric study from July 2012 to July 2014. Vesikari and Clark severity scores were calculated, routine laboratory tests were performed and one stool sample was taken for microbiological testing. RV positive samples were further molecularly analysed. Results A total of 735 (46.8%) samples were RV positive. RV was the most common cause of AGE in all age groups.The majority of RV AGE were recorded in January and February 2014 (93 and 90, respectively). RV-positive patients were younger than RV-negative ones (p = 0.0168). No sigificant differences in laboratory findings were found between two groups of patients. Comparing Vesicari score, more RV-positive patients had moderate to severe illness than RVnegative (p = 0.0015). Using Clark score, no differences were found between groups. G1P8 was the most common RV genotype (60.5%), followed by G2P4 (21.2%), G1P4 (3.3%), G3P8 (3.3%), G2P8 (3%), G9P8 (2.5%). There were significant differences in geographic distribution of RV genotypes (Table 1). Genotype G2P8 was associated with higher Clark and Vesikari scores compared with other genotypes.No significant differences in genotype distribution by age groups and by different seasons were found. Conclusions RV is the most common cause of AGE in Croatian children aged < 5 years. RV genotypes show differences in geographic distribution, as well as in clinical severity of disease.
Rotavirus; Genotype; Croatia
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Podaci o prilogu
835-836.
2016.
objavljeno
Podaci o matičnoj publikaciji
34th Annual Meeting of the ESPID
Brighton:
Podaci o skupu
34th Annual Meeting of the ESPID
poster
10.05.2016-14.05.2016
Brighton, Ujedinjeno Kraljevstvo