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izvor podataka: crosbi

Serotonin transporter gene promoter (5-HTTLPR) and intron 2 (VNTR) polymorphisms in suicide victims of Croatian origin (CROSBI ID 94802)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Hranilović, Dubravka ; Štefulj, Jasminka ; Furač, Ivana ; Kubat, Milovan ; Balija, Melita ; Jernej, Branimir Serotonin transporter gene promoter (5-HTTLPR) and intron 2 (VNTR) polymorphisms in suicide victims of Croatian origin // Biological psychiatry, 54 (2003), 9; 884-889-x

Podaci o odgovornosti

Hranilović, Dubravka ; Štefulj, Jasminka ; Furač, Ivana ; Kubat, Milovan ; Balija, Melita ; Jernej, Branimir

engleski

Serotonin transporter gene promoter (5-HTTLPR) and intron 2 (VNTR) polymorphisms in suicide victims of Croatian origin

Background: Disturbances in serotonin (5HT) transmission are the most frequently reported neurobiological substrates of suicidal behavior. Since 5HT transporter plays an important role in regulation of 5HT synaptic function and its gene contains two functional polymorphisms (5-HTTLPR in the promoter and VNTR in the second intron), it represents an interesting candidate in association studies of suicidal behavior. Methods: In the present study a possible association of 5-HTTLPR and intron 2-VNTR polymorphisms of the 5HT transporter gene with suicidal behavior was investigated in a sample of 135 suicide victims and 299 healthy controls of Croatian origin. Results: Allele frequencies of both polymorphisms in our control population accorded well with the frequencies reported for other European populations. There were no significant differences in the 5-HTTLPR genotype- and allele- frequencies between suicide victims and healthy controls. On the other hand, overrepresentation of VNTR-allele 10 in suicide group (p=0.0485) was observed. Analysis of distribution of estimated haplotype frequencies revealed differences between suicide victims and control subjects (p=0.0168), with the excess of haplotype L10 among suicide victims (p=0.0117). Conclusion: Our results suggest that the intron 2-VNTR polymorphism of 5HT transporter gene might be associated with suicidal behavior and support the involvement of 5HT transporter in susceptibility to suicide.

5-HT transporter; promoter; intron; Slavic population; suicidal behavior

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Podaci o izdanju

54 (9)

2003.

884-889-x

objavljeno

0006-3223

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

Indeksiranost