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Insights into catalytic mechanism of an enzyme


Leščić Ašler, Ivana; Štefanić, Zoran; Luić, Marija
Insights into catalytic mechanism of an enzyme // XVI International Conference on Science, Arts and Culture, INTERNATIONAL CONFERENCE ON SESAME In honour of Paolo Budinich
Veli Lošinj, Hrvatska, 2016. (pozvano predavanje, međunarodna recenzija, pp prezentacija, znanstveni)


Naslov
Insights into catalytic mechanism of an enzyme

Autori
Leščić Ašler, Ivana ; Štefanić, Zoran ; Luić, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, pp prezentacija, znanstveni

Skup
XVI International Conference on Science, Arts and Culture, INTERNATIONAL CONFERENCE ON SESAME In honour of Paolo Budinich

Mjesto i datum
Veli Lošinj, Hrvatska, 29.08-02.09.2016

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
X-ray crystallography; synchrotron radiation; enzymes; mechanism of action

Sažetak
Investigation of the mechanism of enzyme action is maybe the most important aspect of protein research. There is a plethora of methods available to study interactions of an enzyme with its substrates and/or inhibitors. Among those, X-ray crystallography stands out by giving the precise 3D picture of enzyme's active site. In principle, the higher the power of X-rays, the higher the resolution of protein's 3D-structure and more details to be observed. Synchrotrons, as the most powerful X- ray sources, provide in many cases atomic resolution 3D-structures and enable detection of details that could otherwise be obscured. The superiority of synchrotron over in-house X- ray source in study of enzyme's active site will be demonstrated on several protein examples.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
098-1191344-2943 - Protein-ligand međudjelovanja na atomnoj razini (Marija Luić, )
HRZZ-IP-2013-11-7423 - Enzimi purinskog reciklirajućeg ciklusa iz Helicobacter pylori i Escherichie coli (Marija Luić, )

Ustanove
Institut "Ruđer Bošković", Zagreb