engleski

Decrease of Pericytes is Associated With Ligature-Induced Periodontitis Liver Disease in Rats

The aim of this study was to investigate the association between induced periodontitis and the damages caused through its systemic effects on the liver. Twenty rats were divided into two groups: control and periodontitis. The following parameters were evaluated: Gingival Bleeding Index (GBI), Probing Pocket Depth (PPD), Myeloperoxidase (MPO) activity, Alveolar Bone Loss (ABL) for periodontal tissues ; histopathological examination of gingival and liver tissues ; immunohistochemistry to positive cell for neural/glial antigen 2 (NG2) expressed in hepatic pericytes, glutathione (GSH) and malondialdehyde (MDA) concentrations in liver ; serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). GBI, PPD, MPO, ABLs and histopathological examinations demonstrated the development of periodontitis. There was a significant increase in microvesicular steatosis in periodontitis vs. control group, this was accompanied by a marked significantly reduction in NG2+ pericytes, while the level of transaminases remained unchanged. The periodontitis group had significantly lower GSH and higher MDA concentration in the liver compared with the control group. Our results suggest that the induced periodontitis promotes steatosis and reduction of hepatic pericytes, through the increase oxidative stress and lipid peroxidation.

periodontal disease ; steatosis ; glutathione ; malondialdehyde.

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