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Pregled bibliografske jedinice broj: 831562

Electrochemical characterization of biochemically active Cu(II) mixed ligand complex with histidine and cysteine


Mlakar, Marina; Pavković, Sonja; Tumir, Lidija- Marija; Vukosav, Petra; Gašparović, Blaženka
Electrochemical characterization of biochemically active Cu(II) mixed ligand complex with histidine and cysteine // Electroanalysis, 29 (2017), 2; 392-397 doi:10.1002/elan.201600253 (međunarodna recenzija, članak, znanstveni)


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Naslov
Electrochemical characterization of biochemically active Cu(II) mixed ligand complex with histidine and cysteine

Autori
Mlakar, Marina ; Pavković, Sonja ; Tumir, Lidija- Marija ; Vukosav, Petra ; Gašparović, Blaženka

Izvornik
Electroanalysis (1040-0397) 29 (2017), 2; 392-397

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Copper ; histidine ; cysteine ; mixed ligand complexes ; voltammetry

Sažetak
Copper(II) complexes with cysteine and histidine, amino acids that coordinate copper(II) in human body, were investigated. Cu-His and Cu-Cys complexes were detected in pH range from 5.0 to 9.0 using voltammetric techniques. [CuHis2] complex reduces by two- electron reversible process at ≈ -0.40 V, while [CuCys] complex by one-electron quasireversible process at -0.6 V, revealing strong adsorption at the electrode surface. When both amino acids are present in the solution, new peak appeared at -0.5 V, which corresponded to the [CuHisCys] complex reduction. Formation and characterization of mixed ligand complex was also supported by UV-Vis spectra recorded at fixed histidine and various cysteine concentrations. Formation of [CuHisCys] complex in the solution was detected and stability constant calculated to amount to logKCuHisCys=16.9±0.3. This study was the first attempt to characterize formation of Cu(II) mixed ligand complexation process with biochemically important amino acids in electron transport and oxygenation reactions in human body.

Izvorni jezik
Engleski

Znanstvena područja
Geologija, Kemija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-8607 - Utjecaj okolišnog stresa na pojavnost i međudjelovanje biološki važnih organskih molekula i mikronutrijenata u morskom ekosustavu (Blaženka Gašparović, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Citiraj ovu publikaciju

Mlakar, Marina; Pavković, Sonja; Tumir, Lidija- Marija; Vukosav, Petra; Gašparović, Blaženka
Electrochemical characterization of biochemically active Cu(II) mixed ligand complex with histidine and cysteine // Electroanalysis, 29 (2017), 2; 392-397 doi:10.1002/elan.201600253 (međunarodna recenzija, članak, znanstveni)
Mlakar, M., Pavković, S., Tumir, L., Vukosav, P. & Gašparović, B. (2017) Electrochemical characterization of biochemically active Cu(II) mixed ligand complex with histidine and cysteine. Electroanalysis, 29 (2), 392-397 doi:10.1002/elan.201600253.
@article{article, year = {2017}, pages = {392-397}, DOI = {10.1002/elan.201600253}, keywords = {Copper, histidine, cysteine, mixed ligand complexes, voltammetry}, journal = {Electroanalysis}, doi = {10.1002/elan.201600253}, volume = {29}, number = {2}, issn = {1040-0397}, title = {Electrochemical characterization of biochemically active Cu(II) mixed ligand complex with histidine and cysteine}, keyword = {Copper, histidine, cysteine, mixed ligand complexes, voltammetry} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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