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Use of an Octapeptide-Guanidiniocarbonylpyrrole Conjugate for the Formation of a Supramolecular beta-Helix that Self-Assembles into pH-Responsive Fibers


Li, Mao; Radić Stojković, Marijana; Ehlers, Martin; Zellermann, Elio; Piantanida, Ivo; Schmuck, Carsten
Use of an Octapeptide-Guanidiniocarbonylpyrrole Conjugate for the Formation of a Supramolecular beta-Helix that Self-Assembles into pH-Responsive Fibers // Angewandte Chemie. International edition, 55 (2016), 42; 13015-13018 doi:10.1002/anie.201605522 (međunarodna recenzija, članak, znanstveni)


Naslov
Use of an Octapeptide-Guanidiniocarbonylpyrrole Conjugate for the Formation of a Supramolecular beta-Helix that Self-Assembles into pH-Responsive Fibers

Autori
Li, Mao ; Radić Stojković, Marijana ; Ehlers, Martin ; Zellermann, Elio ; Piantanida, Ivo ; Schmuck, Carsten

Izvornik
Angewandte Chemie. International edition (1433-7851) 55 (2016), 42; 13015-13018

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Self-assembly ; molecular recognition ; peptide structure ; ion pair formation ; peptide fibres

Sažetak
Peptides which adopt β-helix structures are predominantly found in transmembrane protein domains or in the lipid bilayer of vesicles. Constructing a β-helix structure in pure water has been considered difficult without the addition of membrane mimics. Herein we report such an example ; peptide 1 which self-assembles into a supramolecular β-helix in pure water based on charge interactions between the individual peptides. Peptide 1 further showed intriguing transitions from small particles to helical fibers in a time dependent process. The fibers can be switched to vesicles by changing the pH value.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-1477 - Višenamjensko očitavanje DNA / RNA sekundarne strukture molekularnim kemijskim senzorima (Ivo Piantanida, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Arts & Humanities Citation Index (A&HCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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