engleski

The Genetic Coding Algorithm For Complementary Peptide Interaction

The results of Biro, Blalock, Root-Bernstein and Siemion showed that peptides specified by the complementary DNA and RNA sequences, i.e., sense and antisense peptides, interact with increased probability. In this study we show that the residue contact energies calculated by the Miyazawa-Jernigan contact potential model support the recognition rules of peptide-peptide interaction based on the complementary coding of DNA and RNA sequences in 3'→5' and 5'→3' directions. The properties of the complementary coding patterns of sense-antisense peptide pairs are closely related to structural diversity, functional specificity and the evolutionary impact of protein and peptide ligand-receptor interactions.

genetic code ; complementary ; protein ; interaction ; symmetry ; chirality

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