The Use of the Miyazawa-Jernigan Residue Contact Potential in Analyses of Molecular Interaction and Recognition with Complementary Peptides (CROSBI ID 638405)
Prilog sa skupa u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Štambuk, Nikola ; Konjevoda, Paško ; Manojlović, Zoran ; Novak Kujundžić, Renata
engleski
The Use of the Miyazawa-Jernigan Residue Contact Potential in Analyses of Molecular Interaction and Recognition with Complementary Peptides
The classic results by Biro, Blalock and Root-Bernstein link genetic code nucleotide patterns to amino acid properties, protein structure and interaction. This study explores the use of the Miyazawa-Jernigan residue contact potential in analyses of protein interaction and recognition between sense and complementary (antisense) peptides. We show that Miyazawa-Jernigan residue contact energies, derived from 3D data, define the recognition rules of peptide-peptide interaction based on the complementary coding of DNA and RNA sequences. The model is strongly correlated with several other chemoinformatic scales often used for the determination of protein antigenic sites and transmembrane regions (Parker et al. r = 0.94 ; Rose et al. r = − 0.92 ; Manavalan-Ponnuswamy r = − 0.92 ; Cornette et al. r = − 0.91 ; Kolaskar-Tongaonkar r = − 0.91 ; Grantham r = 0.90 ; White-Wimley (octanol) r = − 0.88 ; Kyte-Doolittle r = − 0.85). The algorithms presented have important biomedical and proteomic applications related to modulation of the peptide-receptor function and epitope-paratope interaction, the design of lead compounds and the development of new immunochemical assays and diagnostic procedures.
contact; potential; protein-protein; interaction; peptide; binding
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Podaci o prilogu
91-102.
2016.
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objavljeno
Podaci o matičnoj publikaciji
Lecture notes in computer science
Ortuño, Francisco ; Rojas, Ignacio
Cham: Springer
978-3-319-31743-4
0302-9743
Podaci o skupu
4th International Work-Conference on Bioinformatics and Biomedical Engineering (IWBBIO 2016)
predavanje
20.04.2016-22.04.2016
Granada, Španjolska