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Pregled bibliografske jedinice broj: 830263

Acid-base Properties and Kinetics of Hydrolysis of Aroylhydrazones Derived from Nicotinic Acid Hydrazide


Benković, Tomislav; Kontrec, Darko; Tomišić, Vladislav; Budimir, Ana; Galić, Nives
Acid-base Properties and Kinetics of Hydrolysis of Aroylhydrazones Derived from Nicotinic Acid Hydrazide // Journal of solution chemistry, 45 (2016), 8; 1227-1245 doi:10.1007/s10953-016-0504-8 (međunarodna recenzija, članak, znanstveni)


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Naslov
Acid-base Properties and Kinetics of Hydrolysis of Aroylhydrazones Derived from Nicotinic Acid Hydrazide

Autori
Benković, Tomislav ; Kontrec, Darko ; Tomišić, Vladislav ; Budimir, Ana ; Galić, Nives

Izvornik
Journal of solution chemistry (0095-9782) 45 (2016), 8; 1227-1245

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
aromatic hydrazones ; HPLC ; hydrolysis ; mass spectrometry ; protonation constants ; UV spectrometry

Sažetak
A series of aroylhydrazones were synthesized from nicotinic acid hydrazide and differently substituted benzaldehydes. The protonation constants of hydrazones 1 to 12, as well as of starting compounds, were determined in methanol/water 1/1 mixture by spectrophotometric-potentiometric batch titrations. In order to determine the effect of substituent on the stability of C=N bond, the kinetics of hydrolysis of hydrazones was studied spectrophotometrically in acidic and basic media. HPLC method was used for investigation of hydrolysis of selected compounds, for which equilibrium between hydrolysis and condensation reaction was noticed. The observed rate constants, calculated from chromatographic and spectrophotometric data were in good agreement. Electrospray mass spectrometry was used for determination of reaction products. The oxidation and formation of quinones in basic media were observed for 2, 3- and 2, 5-dihydroxy substituted benzaldehyde derivatives. On the other hand, the 2, 4-dihydroxy derivative showed higher stability compared to Nʹ-salicylidene-3- pyridinecarbohydrazide.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2014-09-4841 - Aromatski hidrazoni: sinteza, strukturna analiza, biološka aktivnost i analitička primjena (ARHYD) (, HRZZ - 2014-09 )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Citiraj ovu publikaciju

Benković, Tomislav; Kontrec, Darko; Tomišić, Vladislav; Budimir, Ana; Galić, Nives
Acid-base Properties and Kinetics of Hydrolysis of Aroylhydrazones Derived from Nicotinic Acid Hydrazide // Journal of solution chemistry, 45 (2016), 8; 1227-1245 doi:10.1007/s10953-016-0504-8 (međunarodna recenzija, članak, znanstveni)
Benković, T., Kontrec, D., Tomišić, V., Budimir, A. & Galić, N. (2016) Acid-base Properties and Kinetics of Hydrolysis of Aroylhydrazones Derived from Nicotinic Acid Hydrazide. Journal of solution chemistry, 45 (8), 1227-1245 doi:10.1007/s10953-016-0504-8.
@article{article, year = {2016}, pages = {1227-1245}, DOI = {10.1007/s10953-016-0504-8}, keywords = {aromatic hydrazones, HPLC, hydrolysis, mass spectrometry, protonation constants, UV spectrometry}, journal = {Journal of solution chemistry}, doi = {10.1007/s10953-016-0504-8}, volume = {45}, number = {8}, issn = {0095-9782}, title = {Acid-base Properties and Kinetics of Hydrolysis of Aroylhydrazones Derived from Nicotinic Acid Hydrazide}, keyword = {aromatic hydrazones, HPLC, hydrolysis, mass spectrometry, protonation constants, UV spectrometry} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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