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ESI-MS studies of the non-covalent interactions between biologically important metal ions and N- sulfonylcytosine derivatives

The aim of this report is to present the electrospray ionization (ESI-MS) results of the non-covalent interaction of two biologically active ligands, N-1-(p-toluenesulfonyl)cytosine, 1-TsC, 1 and N-1-methanesulfonylcytosine, 1-MsC, 2 and their Cu(II) complexes Cu(1-TsC-N3)2Cl2, 3 and Cu(1-MsC-N3)2Cl2, 4 with biologically important cations: Na+, K+, Ca2+, Mg2+ and Zn2+. The formation of various complex metal ions was observed. The alkali metals Na+ and K+ formed clusters due to electrostatic interactions. Ca2+ and Mg2+ salts produced the tris ligand and mixed ligand complexes. The interaction of Zn2+ with 1-4 produced monometal and dimetal Zn2+ complexes as a result of the affinity of Zn2+ ions towards both O and N atoms.

N-1-sulfonylcytosine derivatives ; Cu(II) complexes ; metal ions Na+ ; K+ ; Ca2+ ; Mg2+ ; Zn2+ ; non-covalent interactions ; ESI-MS

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