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TRIPEPTIDE HYDROGELATOR (Ac-FFA-NH2) AS A MODEL OF BINDING SITE Aβ-PROTEIN ; COMPARATIVE BINDING STUDIES WITH THIOFLAVIN T AND OTHER Aβ- BINDERS


Pospišil, Tihomir; Žinić, Mladen; Frkanec, Leo
TRIPEPTIDE HYDROGELATOR (Ac-FFA-NH2) AS A MODEL OF BINDING SITE Aβ-PROTEIN ; COMPARATIVE BINDING STUDIES WITH THIOFLAVIN T AND OTHER Aβ- BINDERS // Czech Chemical Society Symposium Series, 14 (2016), 3; 126-126a (podatak o recenziji nije dostupan, sažetak s kongresa, znanstveni)


Naslov
TRIPEPTIDE HYDROGELATOR (Ac-FFA-NH2) AS A MODEL OF BINDING SITE Aβ-PROTEIN ; COMPARATIVE BINDING STUDIES WITH THIOFLAVIN T AND OTHER Aβ- BINDERS

Autori
Pospišil, Tihomir ; Žinić, Mladen ; Frkanec, Leo

Izvornik
Czech Chemical Society Symposium Series (2336-7202) 14 (2016), 3; 126-126a

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, sažetak s kongresa, znanstveni

Ključne riječi
Aβ-amyloid aggregates ; Supramolecular self assembly ; Low molecular weight peptidic gelators ; Binding of histological dyes

Sažetak
Series of tripeptide FFA derivatives was synthesized and tested for gelation of water and organic solvents. Only Ac-FFA-NH2 tripeptide exhibited gelation of water by self- assembly under physiological conditions. TEM of the Ac- FFA-NH2 hydrogel and the methanol/water gel showed the presence of straight fibers with relatively uniform diameters of around 50 nm. FTIR and NMR investigation pointed toward the cross-β structure type of hydrogen bonding of the tripeptide in the gel aggregates. Conjugated dyes (Thioflavin T and Congo Red) are commonly used to stain the plaques in histopathological studies3. Fluorescence titration of Ac-FFA-NH2 aqueous solution bellow its minimal gelation concentration with Thioflavin T (ThT) showed increase of ThT emission with increased tripeptide concentration and formation of the 1 : 1 complex with significant association constant.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
098-0982904-2912 - Samo-udruživanje u gelovima i sinteza funkcionalnih hibridnih materijala (Leo Frkanec, )
HRZZ-IP-1-2013-7387

Ustanove
Institut "Ruđer Bošković", Zagreb

Uključenost u ostale bibliografske baze podataka:


  • Chemoreception Abstracts
  • Chemical Titles
  • Science Citation Index