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Templated nucleotide addition and immunoglobulin JH-gene utilization in t(11;14) junctions: Implications for the mechanism of translocation and the origin of mantle cell lymphoma. (CROSBI ID 94764)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Welzel, Natascha ; Le, Trang ; Marculescu, Rodrig ; Mitterbauer, Gerlinde ; Chott, Andreas ; Pott, Christine ; Kneba, Michael ; Du, Ming-Qing ; Kušec, Rajko ; Drach, Johanes et al. Templated nucleotide addition and immunoglobulin JH-gene utilization in t(11;14) junctions: Implications for the mechanism of translocation and the origin of mantle cell lymphoma. // Cancer research (Baltimore), 61 (2001), 1629-1636-x

Podaci o odgovornosti

Welzel, Natascha ; Le, Trang ; Marculescu, Rodrig ; Mitterbauer, Gerlinde ; Chott, Andreas ; Pott, Christine ; Kneba, Michael ; Du, Ming-Qing ; Kušec, Rajko ; Drach, Johanes ; Raderer, Markus ; Mannhalter, Christine ; Lechner, Klaus ; Nadel, Bertrand ; Jaeger, Ulrich

engleski

Templated nucleotide addition and immunoglobulin JH-gene utilization in t(11;14) junctions: Implications for the mechanism of translocation and the origin of mantle cell lymphoma.

The t(11;14) (q13;q32) between the BCL-1 and immunoglobulin heavy chain gene (Ig-H) loci in mantle cell lymphomy (MCL) are believed to be mediated by the mechanism of V(D)J recombination similar to the t(14;18) in follicular lymphoma. We have recently shown that the t(14;18) event creates staggered double-strand breaks in the BC-2 locus, and that the t(14;18) junctions contain templated nucleotide insertions (T-nucleotides)...

template nucleotide addition; JH-gene utilization; mantle cell lymphoma

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Podaci o izdanju

61

2001.

1629-1636-x

objavljeno

0008-5472

1538-7445

Povezanost rada

Kliničke medicinske znanosti