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Pregled bibliografske jedinice broj: 827890

The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection


Jaillon, Sébastien; Moalli, Federica; Ragnarsdottir, Bryndis; Bonavita, Eduardo; Puthia, Manoj; Riva, Federica; Barbati, Elisa; Nebuloni, Manuela; Cvetko Krajinovic, Lidija; Markotic, Alemka et al.
The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection // Immunity, 40 (2014), 4; 621-632 doi:10.1016/j.immuni.2014.02.015 (međunarodna recenzija, članak, znanstveni)


Naslov
The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection

Autori
Jaillon, Sébastien ; Moalli, Federica ; Ragnarsdottir, Bryndis ; Bonavita, Eduardo ; Puthia, Manoj ; Riva, Federica ; Barbati, Elisa ; Nebuloni, Manuela ; Cvetko Krajinovic, Lidija ; Markotic, Alemka ; Valentino, Sonia ; Doni, Andrea ; Tartari, Silvia ; Graziani, Giorgio ; Montanelli, Alessandro ; Delneste, Yves ; Svanborg, Catharina ; Garlanda, Cecilia ; Mantovani, Alberto

Izvornik
Immunity (1074-7613) 40 (2014), 4; 621-632

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
PTX3 ; innate immunity ; uroinfections

Sažetak
Immunity in the urinary tract has distinct and poorly understood pathophysiological characteristics and urinary tract infections (UTIs) are important causes of morbidity and mortality. We investigated the role of the soluble pattern recognitionmolecule pentraxin 3 (PTX3), a key component of the humoral arm of innate immunity, in UTIs. PTX3-deficient mice showed defective control of UTIs and exacerbated inflammation. Expression of PTX3 was induced in uroepithelial cells by uropathogenic Escherichia coli (UPEC) in a Toll-like receptor 4 (TLR4)- and MyD88- dependent manner. PTX3 enhanced UPEC phagocytosis and phagosome maturation by neutrophils. PTX3 was detected in urine of UTI patients and amounts correlated with disease severity. In cohorts of UTI-prone patients, PTX3 gene polymorphisms correlated with susceptibility to acute pyelonephritis and cystitis. These results suggest that PTX3 is an essential component of innate resistance against UTIs. Thus, the cellular and humoral arms of innate immunity exert complementary functions in mediating resistance against UTIs.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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