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Pregled bibliografske jedinice broj: 825990

1, 2, 3-Triazole appended L-ascorbic acid with antioxidant properties


Meščić, Andrijana; Harej, Anja; Kraljević Pavelić, Sandra; Stepanić, Višnja; Raić-Malić, Silvana
1, 2, 3-Triazole appended L-ascorbic acid with antioxidant properties // 17th Tetrahedron Symposium Challenges in Biological, Bioorganic, Organic & Medicinal Chemistry
Sitges, Španjolska, 2016. str. 1-1 (poster, nije recenziran, sažetak, ostalo)


Naslov
1, 2, 3-Triazole appended L-ascorbic acid with antioxidant properties

Autori
Meščić, Andrijana ; Harej, Anja ; Kraljević Pavelić, Sandra ; Stepanić, Višnja ; Raić-Malić, Silvana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
17th Tetrahedron Symposium Challenges in Biological, Bioorganic, Organic & Medicinal Chemistry / - , 2016, 1-1

Skup
17th Tetrahedron Symposium Challenges in Biological, Bioorganic, Organic & Medicinal Chemistry

Mjesto i datum
Sitges, Španjolska, 28.06.-01.07.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
L-askorbinska kiselina ; 1 ; 2 ; 3-triazol ; hvatač radikala ; antitumorski agens
(L-ascorbic acid ; 123-triazole ; radical scavenging ; antitumoral agent)

Sažetak
Since the discovery of vitamin C, the number of its known biological functions is continually expanding. Various pyrimidines and purines containing L-ascorbic acid exhibited significant antiproliferative effects against malignant human tumour cell lines.1 Vitamin C is a biologically significant reducing agent due to its 1-oxo-2- ene-2, 3-diol structural moiety. Furthermore, 1, 2, 3-triazoles have attracted considerable attention in recent years because of their wide range of biological activities against various viruses, malignant cells, microorganisms and their inhibitory activities against several enzymes.2 A series of 1, 4-substituted 1, 2, 3-triazole derivatives of L-ascorbic acid have been synthesized as potential antitumor compounds. The influence of the substituent R2 at the C-4 of the triazole ring on the radical scavenging capacity was also examined. Results of the biological evaluations of novel compounds will be presented.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-5596 - SINTEZA I CITOSTATSKA ISPITIVANJA BIBLIOTEKE NOVIH DUŠIKOVIH HETEROCIKLA (Silvana Raić-Malić, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb