engleski

Assessing human environmental aluminum exposure by analyzing frequency distribution properties of hair and whole blood aluminum concentrations

Aluminum is an omnipresent non-essential trače element in the human diet and an essential component of numerous industrial processes. The Al population exposure risk is increasing, but there is no long-term biomarker for the exposure assessment. We analyzed Al with ICP MS in the hair (AIH) and whole blood (A'WB) in 311 healthy persons (ncJ = 123 and n^ = 188) ; the AIWB was analyzed in 142 women and 90 men. We used the median derivative power function to assess aluminum exposure. AIH median was higher in men (6.64) than in women (4.74 pgg') (p < 0.01, x2- test). AIWB was below detection limit of 0.09 pgml1 in over half the men and vvomen. AIH concentrations below or above the linear segment (Tolerable exposure) of 1.98-14.3 in women and 2.78-17.5 pg-g1 in men indicate Low or the Excessive exposure, respec- tively. AIWB of 0.09- 1.53 |ig g1 indicates the Tollerable Al exposure ; AIWB and AIH were poorly correlated. The Tollerable AIH exposure can be further differentiated by a 3-component kinetic analysis to reflect the changes of hair aluminum saturation capacity. The median derivative power function for analyzing AIH frequency distribution is a valuable long-term biomarker for assessing the population environmental aluminum exposure risk.

aluminum ; population exposure ; biomarkers ; hair ; whole blood ; median derivatives ; risk assessment

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