engleski

Friedel-Crafts acylations in ball-mill

Friedel-Crafts acylation reactions were exploited in the preparation of aromatic ketones. For this purpose, solvent-free mechanochemical reaction conditions of this industrially important reaction were developed. Reaction parameters such as FC catalyst, time, ratio of reagents, milling support, frequency of milling, size and number of milling balls, solvents for liquid assisted grinding were studied to establish the optimal reaction conditions. To explore the scope of the reaction, different aromatic hydrocarbons were used in conjuction with anhydrides and acyl halides. It was shown that certain FC reactive aromatics could be effectively functionalized by FC acylations carried out in ball-milling conditions without the presence of solvent. Some aspects of reaction mechanism were also explored by in situ reaction monitoring by Raman spectroscopy.

organic synthesis; green chemistry; mechanochemistry; Friedel-Crafts

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