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Novel Carbohydrate Induced Modification of Peptides: Crystal Structure and NMR Analysis of Ester-Bridged Bicyclic Galactose-Enkephalin Adduct Containing Imidazolidinone Moiety

Comparative studies based on X-ray crystallography and NMR spectroscopy were used for structural characterization of the novel minor, imidazolidinone moiety containing, product of the Maillard reaction obtained in vitro by using the galactose-modified endogenous opioid pentapeptide leucine-enkephalin (Tyr-Gly-Gly-Phe-Leu).

X-ray structure analysis; NMR spectroscopy; conformational analysis; leucine-enkephalin; imidazolidinone; carbohydrate; galactose; glycation

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