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Pregled bibliografske jedinice broj: 822230

Strong osteopontin expression in tumor-associated macrophages is predictor of better prognosis in oral Squamous Cell Carcinoma (SCC)


Lučin, Ksenija; Avirović, Manuela; Matušan Ilijaš, Koviljka; Cerović, Robert; Juretić, Mirna; Jonjić, Nives
Strong osteopontin expression in tumor-associated macrophages is predictor of better prognosis in oral Squamous Cell Carcinoma (SCC) // Pathology - breaking barriers in medicine ; Virchows Archiv
Belgrade, Serbia, 2015. str. S89-S89 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Strong osteopontin expression in tumor-associated macrophages is predictor of better prognosis in oral Squamous Cell Carcinoma (SCC)

Autori
Lučin, Ksenija ; Avirović, Manuela ; Matušan Ilijaš, Koviljka ; Cerović, Robert ; Juretić, Mirna ; Jonjić, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Pathology - breaking barriers in medicine ; Virchows Archiv / - , 2015, S89-S89

Skup
27th European Congress of Pathology

Mjesto i datum
Belgrade, Serbia, 05.-09. September

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Osteopontin; Squamous Cell Carcinoma; Tumor associated macrophages

Sažetak
Objective: Osteopontin (OPN) is a glycoprotein involved in progression of many carcinomas, including oral squamous cell carcinoma (OSCC). It is synthesized by a variety of epithelial and mesenchymal cell types, including macrophages. Recently, a distinct activities of OPN from stromal and parenchymal tumor cells has been proposed. The aim of this study was to evaluate the expression of osteopontin in tumor-associated macrophages (TAMs) from OSCC tissue and to determine its possible prognostic significance. Method: The expression of OPN was immunohistochemicaly analyzed in TAMs from 86 OSCC and compared with clinicopathological variables. The staining intensity was semi-quantitatively assessed as high, moderate and low. Results: Diffusecytoplasmic positivity for OPN in infiltrating TAMs was classified as high in 21 patients, moderate in 47 patients, and low in 14 patients ; OPN+ macrophages were absent in 4 patients. Strong OPN expression in TAMs was associated with low invasive front grade (p < 0.006), low level of inflammatory response ( p< 0.018), and a better disease specific survival (p= 0.009). Expression patterns were not asso- ciated with pTstage (p= 0.28), lymph node status ( p= 0.21), nor with the WHO clinical stage (p =0.41). Conclusion: In OSCC macrophage-derived OPN probably has a different function compared with OPN secreted from tumor cells.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
(poster, međunarodna recenzija, sažetak, znanstveni)



POVEZANOST RADA


Projekt / tema
062-0620095-0078 - Uloga osteopontina u progresiji tumora (Ksenija Lučin, )

Ustanove
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Lučin, Ksenija; Avirović, Manuela; Matušan Ilijaš, Koviljka; Cerović, Robert; Juretić, Mirna; Jonjić, Nives
Strong osteopontin expression in tumor-associated macrophages is predictor of better prognosis in oral Squamous Cell Carcinoma (SCC) // Pathology - breaking barriers in medicine ; Virchows Archiv
Belgrade, Serbia, 2015. str. S89-S89 (poster, međunarodna recenzija, sažetak, znanstveni)
Lučin, K., Avirović, M., Matušan Ilijaš, K., Cerović, R., Juretić, M. & Jonjić, N. (2015) Strong osteopontin expression in tumor-associated macrophages is predictor of better prognosis in oral Squamous Cell Carcinoma (SCC). U: Pathology - breaking barriers in medicine ; Virchows Archiv.
@article{article, year = {2015}, pages = {S89-S89}, keywords = {Osteopontin, Squamous Cell Carcinoma, Tumor associated macrophages}, title = {Strong osteopontin expression in tumor-associated macrophages is predictor of better prognosis in oral Squamous Cell Carcinoma (SCC)}, keyword = {Osteopontin, Squamous Cell Carcinoma, Tumor associated macrophages}, publisherplace = {Belgrade, Serbia} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE