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Pregled bibliografske jedinice broj: 821273

Gabapentin-induced changes of plasma cortisol level and immune status in hysterectomized women


Orlić Karbić, Vlasta; Škoda, Marko; Antončić, Dragana; Krištofić, Ines; Komar, Daniela; Trobonjača, Zlatko
Gabapentin-induced changes of plasma cortisol level and immune status in hysterectomized women // International immunopharmacology, 23 (2014), 2; 530-536 doi:10.1016/j.intimp.2014.09.029 (međunarodna recenzija, članak, znanstveni)


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Naslov
Gabapentin-induced changes of plasma cortisol level and immune status in hysterectomized women

Autori
Orlić Karbić, Vlasta ; Škoda, Marko ; Antončić, Dragana ; Krištofić, Ines ; Komar, Daniela ; Trobonjača, Zlatko

Izvornik
International immunopharmacology (1567-5769) 23 (2014), 2; 530-536

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Gabapentin ; Immunomodulation ; Immune status ; Hysterectomy

Sažetak
We have examined the effects of gabapentin (GBP) on stress-related changes of cortisol and catecholamines in patients who underwent hysterectomy because of uterine fibrinoids. Additionally, we have observed the effect of GBP on the immune status in the acute stress response to surgery.Sixty patients scheduled for an abdominal hysterectomy were randomly assigned to the GBP administration 1 h before surgery (n = 30 pts), or to the placebo group (n = 30 pts). Blood samples were collected before and 24 h after the surgery. The intensity of pain was assessed by a visual analogue scale (VAS) every 8 h at rest. Immunomodulatory effects of GBP were determined by flow cytometry. We followed the total proportion of CD3+ lymphocytes, CD3+CD4+, CD3+CD8+, CD19+ B lymphocytes, CD16+CD56+CD3−NK cells and CD16+CD56+CD3+ NKT cells before and 24 h after hysterectomy. The plasma cortisol and catecholamines concentration was used to estimate the level of the stress response. VAS pain score at rest was significantly lower in the GBP group than in the placebo group (P = 0.003). Application of GBP significantly decreased the plasma cortisol level 24 h after the operation in comparison to the placebo group (P < 0, 001). We found significant positive correlation between the VAS pain score and concentration of cortisol in all patients (P = 0.025). GBP reduced the concentration of catecholamines (p < 0.05). The proportion of CD3+ (P = 0.027) and CD3+CD4+cells (P = 0.006) was significantly lower in the GBP group 24 h after operation, while the contribution of CD19+ (P = 0.033) was significantly higher. Preoperative administration of GBP reduced the pain scores at rest in patients at 0, 16 and 24 h after abdominal hysterectomy. Additionally, GBP reduced the stress response and changed immune parameters in the reaction to surgery.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
0062064
062-0000000-3544 - Antigen predočne stanice u jetri miša tijekom citomegalovirusne infekcije (Trobonjača, Zlatko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Citiraj ovu publikaciju:

Orlić Karbić, Vlasta; Škoda, Marko; Antončić, Dragana; Krištofić, Ines; Komar, Daniela; Trobonjača, Zlatko
Gabapentin-induced changes of plasma cortisol level and immune status in hysterectomized women // International immunopharmacology, 23 (2014), 2; 530-536 doi:10.1016/j.intimp.2014.09.029 (međunarodna recenzija, članak, znanstveni)
Orlić Karbić, V., Škoda, M., Antončić, D., Krištofić, I., Komar, D. & Trobonjača, Z. (2014) Gabapentin-induced changes of plasma cortisol level and immune status in hysterectomized women. International immunopharmacology, 23 (2), 530-536 doi:10.1016/j.intimp.2014.09.029.
@article{article, author = {Orli\'{c} Karbi\'{c}, Vlasta and \v{S}koda, Marko and Anton\v{c}i\'{c}, Dragana and Kri\v{s}tofi\'{c}, Ines and Komar, Daniela and Trobonja\v{c}a, Zlatko}, year = {2014}, pages = {530-536}, DOI = {10.1016/j.intimp.2014.09.029}, keywords = {Gabapentin, Immunomodulation, Immune status, Hysterectomy}, journal = {International immunopharmacology}, doi = {10.1016/j.intimp.2014.09.029}, volume = {23}, number = {2}, issn = {1567-5769}, title = {Gabapentin-induced changes of plasma cortisol level and immune status in hysterectomized women}, keyword = {Gabapentin, Immunomodulation, Immune status, Hysterectomy} }
@article{article, author = {Orli\'{c} Karbi\'{c}, Vlasta and \v{S}koda, Marko and Anton\v{c}i\'{c}, Dragana and Kri\v{s}tofi\'{c}, Ines and Komar, Daniela and Trobonja\v{c}a, Zlatko}, year = {2014}, pages = {530-536}, DOI = {10.1016/j.intimp.2014.09.029}, keywords = {Gabapentin, Immunomodulation, Immune status, Hysterectomy}, journal = {International immunopharmacology}, doi = {10.1016/j.intimp.2014.09.029}, volume = {23}, number = {2}, issn = {1567-5769}, title = {Gabapentin-induced changes of plasma cortisol level and immune status in hysterectomized women}, keyword = {Gabapentin, Immunomodulation, Immune status, Hysterectomy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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