engleski

Physiological Role of IL-15 and IL-18 at the Maternal-Fetal Interface (CC)

Here, we review recent studies about two cytokines IL-15 and IL-18, showing that they are the critical cytokines controlling uterine NK cell cytokine production and cytolytic potential. Further, IL-15 has been implicated in differentiation and proliferation of uterine NK cells, while IL-18 enhanced innate immunity and both Th1- and Th2-driven immune responses depending of cytokine milieu. We addressed possible role of these two cytokines in induction of the IFN-gamma production as a key molecule in vascular remodeling during early pregnancy.

interleukin-15, interleukin-18, NK cells, pregnancy

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