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Soluble TREM-1: lung and serum level in patients with bacterial VAP

Introduction: Human soluble Triggering Receptor Expressed on Myeloid Cells (sTREM-1) is 3o-kDa glycoprotein of immunoglobulin superfamily. In normal lung tissue TREM-1 is selectively expressed in lung alveolar macrophages, specialised in patogen clearens and is upregulated in the presence of bacteria and fungi. The aim of this study was to asses levels sTREM-1 in serum and lungs in patients with VAP. Methods: Cohort study include 31 patient contented criteria for ventilator associated pneumonia (VAP). Criteria enclose clinical, microbiologically, radiologically and labaratory findings in mechanically ventilated patients more than 48 hours and Clinical Pulmonary Infection Score (CPIS) > 6. Serum and lung level of sTREM-1 was obtained and the difference tested. The samples were analysed using ELISA technique and values expressed in pg/ml. Specimens for lung sTREM-1 were obtained in non directed bronchial lavage fluid and the serum speciments from peripheral blood. Data difference were tested by Mann Whitney U test with p < 0, 05 as significant. Results: There is a statistical significanse difference among sTREM-1 levels from serum and lungs in patients vith bacterial VAP (p < 0, 05 ; Z = 6), with very high levels of sTREM-1 in lung speciments (mean value 1565 pg/l). Conclusion: Soluble TREM-1 is in high concentration expressed in lung speciments patients with bacterial VAP. Levels of sTREM-1 can help in diagnosis bacterial pneumonia as standalone marker.

sTREM-1; bacterial; ventilator associated pneumonia; bronchial lavage fluid

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