REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION (CROSBI ID 636078)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Marinković, Mija ; Rogov, Vladimir ; Suzuki, Hironori ; Buljubašić, Maja ; lang, Verena ; Šprung, Matilda ; Kato, Ryuichi ; Kawasaki, Masato ; Hamacher- Brady, Anne ; Dötsch, Volker ; Wakatsuki, Soichi ; Brady, Nathan ; Dikic, Ivan ; Novak, Ivana
engleski
REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION
Discoveries of autophagic receptors that recognize specific cellular cargo have opened a new chapter in autophagy field. Selective removal of damaged organelles or protein aggregates is essential for the proper cellular homeostasis and survival. We have recently identified and characterized Nix/Bnip3 and Bnip3 mitochondrial proteins as mitophagy receptors that, in LIR-dependent manner, interact with Atg/LC3/GABARAP proteins and recruit autophagic machinery to damaged mitochondria. Moreover, we have shown that Nix/Bnip3L mediated mitochondrial clearance during reticulocyte differentiation. At the moment, we are investigating the phosphorylation status of Nix/Bnip3L and Bnip3 in regulation of mitophagy. Our current results show that phosphorylation of mitophagy receptors Nix/Bnip3L and Bnip3 are essential for the initiation of mitochondrial sequestration by autophagic machinery and are involved in fine-tuning of mitophagy.
Autophagy ; mitophagy ; receptors ; phosphorylation
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Podaci o prilogu
1-2.
2016.
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objavljeno
Podaci o matičnoj publikaciji
Congress of the Croatian Society of Biochemistry and Molecular Biology, HDBMB2016
Podaci o skupu
Congress of the Croatian Society of Biochemistry and Molecular Biology, HDBMB2016
poster
01.06.2016-04.06.2016
Split, Hrvatska