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Pregled bibliografske jedinice broj: 819852

REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION


Marinković, Mija; Rogov, Vladimir; Suzuki, Hironori; Buljubašić, Maja; lang, Verena; Šprung, Matilda; Kato, Ryuichi; Kawasaki, Masato; Hamacher- Brady, Anne; Dötsch, Volker et al.
REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION // Congress of the Croatian Society of Biochemistry and Molecular Biology, HDBMB2016
Split, 2016. str. 1-2 (poster, nije recenziran, sažetak, znanstveni)


CROSBI ID: 819852 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION

Autori
Marinković, Mija ; Rogov, Vladimir ; Suzuki, Hironori ; Buljubašić, Maja ; lang, Verena ; Šprung, Matilda ; Kato, Ryuichi ; Kawasaki, Masato ; Hamacher- Brady, Anne ; Dötsch, Volker ; Wakatsuki, Soichi ; Brady, Nathan ; Dikic, Ivan ; Novak, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Congress of the Croatian Society of Biochemistry and Molecular Biology, HDBMB2016 / - , 2016, 1-2

Skup
Congress of the Croatian Society of Biochemistry and Molecular Biology, HDBMB2016

Mjesto i datum
Split, 01-04.06.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Autophagy ; mitophagy ; receptors ; phosphorylation

Sažetak
Discoveries of autophagic receptors that recognize specific cellular cargo have opened a new chapter in autophagy field. Selective removal of damaged organelles or protein aggregates is essential for the proper cellular homeostasis and survival. We have recently identified and characterized Nix/Bnip3 and Bnip3 mitochondrial proteins as mitophagy receptors that, in LIR-dependent manner, interact with Atg/LC3/GABARAP proteins and recruit autophagic machinery to damaged mitochondria. Moreover, we have shown that Nix/Bnip3L mediated mitochondrial clearance during reticulocyte differentiation. At the moment, we are investigating the phosphorylation status of Nix/Bnip3L and Bnip3 in regulation of mitophagy. Our current results show that phosphorylation of mitophagy receptors Nix/Bnip3L and Bnip3 are essential for the initiation of mitochondrial sequestration by autophagic machinery and are involved in fine-tuning of mitophagy.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-UIP-2013-11-5246 - Uloga receptora autofagije u selektivnom uklanjanju mitohondrija (AutoMito) (Novak Nakir, Ivana, HRZZ - 2013-11) ( POIROT)

Ustanove:
Prirodoslovno-matematički fakultet, Split,
Medicinski fakultet, Split


Citiraj ovu publikaciju

Marinković, Mija; Rogov, Vladimir; Suzuki, Hironori; Buljubašić, Maja; lang, Verena; Šprung, Matilda; Kato, Ryuichi; Kawasaki, Masato; Hamacher- Brady, Anne; Dötsch, Volker et al.
REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION // Congress of the Croatian Society of Biochemistry and Molecular Biology, HDBMB2016
Split, 2016. str. 1-2 (poster, nije recenziran, sažetak, znanstveni)
Marinković, M., Rogov, V., Suzuki, H., Buljubašić, M., lang, V., Šprung, M., Kato, R., Kawasaki, M., Hamacher- Brady, A. & Dötsch, V. (2016) REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION. U: Congress of the Croatian Society of Biochemistry and Molecular Biology, HDBMB2016.
@article{article, year = {2016}, pages = {1-2}, keywords = {Autophagy, mitophagy, receptors, phosphorylation}, title = {REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION}, keyword = {Autophagy, mitophagy, receptors, phosphorylation}, publisherplace = {Split} }
@article{article, year = {2016}, pages = {1-2}, keywords = {Autophagy, mitophagy, receptors, phosphorylation}, title = {REGULATION OF MITOPHAGY RECEPTORS BY PHOSPHORYLATION}, keyword = {Autophagy, mitophagy, receptors, phosphorylation}, publisherplace = {Split} }




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