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Pregled bibliografske jedinice broj: 819760

Apoptosis mediated by cytolytic molecules might be responsible for maintenance of psoriatic plaques


Kaštelan, Marija; Prpić-Massari, Larisa; Brajac, Ines
Apoptosis mediated by cytolytic molecules might be responsible for maintenance of psoriatic plaques // Medical hypotheses, 67 (2006), 2; 336-337 doi:10.1016/j.mehy.2006.01.051 (međunarodna recenzija, članak, znanstveni)


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Naslov
Apoptosis mediated by cytolytic molecules might be responsible for maintenance of psoriatic plaques

Autori
Kaštelan, Marija ; Prpić-Massari, Larisa ; Brajac, Ines

Izvornik
Medical hypotheses (0306-9877) 67 (2006), 2; 336-337

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
apoptosis ; perforin ; psoriasis

Sažetak
Psoriasis is a chronic hyperproliferative skin disease characterized by keratinocyte hyperproliferation and inflammation. It is generally considered as an autoimmune disease mediated by T cells. The precise mechanism of triggering keratinocyte hyperproliferation is as yet unknown. Apoptosis seems to be important in the maintenance of skin cell homeostasis as well as in the pathogenesis of some skin diseases. We hypothesize how apoptosis mediated by cytolytic mechanisms could be involved in initiating and maintenance of psoriatic plaque. Increased keratinocyte hyperproliferation might develop as a consequence of failure to remove self-reactive T cells by apoptosis that in other way cause significant keratinocyte damage. Apoptotic keratinocytes might trigger an injury response program causing regenerative hyperplasia of epidermal keratinocytes. Another possibility is that the failure to eliminate these abnormal keratinocytes could result in the persistence of chronic inflammatory conditions constantly recruiting specific T cells. Increased epidermal thickness in psoriasis could be also explained by imbalance between the expression of pro- and anti-apoptotic proteins. Epidermal keratinocytes have the ability to produce cytolytic molecules, thus they might also have the potential to protect the epidermis from T cell-mediated damage. In conclusion, hyperproliferation of psoriatic keratinocytes might be partly due to changes in the keratinocyte expression of pro- and anti-apoptotic genes, partly to the damaged keratinocytes triggering an inappropriate wound repair response and partly by the failure to eliminate these abnormal keratinocytes resulting in the persistence of chronic inflammation. Each of the proposed mechanisms might be a possible therapeutic target mainly by new immunomodulatory agents.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
0062063
0062040

Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Profili:

Avatar Url Larisa Prpić Massari (autor)

Avatar Url Ines Brajac (autor)

Avatar Url Marija Kaštelan (autor)

Poveznice na cjeloviti tekst rada:

doi www.medical-hypotheses.com www.sciencedirect.com

Citiraj ovu publikaciju:

Kaštelan, Marija; Prpić-Massari, Larisa; Brajac, Ines
Apoptosis mediated by cytolytic molecules might be responsible for maintenance of psoriatic plaques // Medical hypotheses, 67 (2006), 2; 336-337 doi:10.1016/j.mehy.2006.01.051 (međunarodna recenzija, članak, znanstveni)
Kaštelan, M., Prpić-Massari, L. & Brajac, I. (2006) Apoptosis mediated by cytolytic molecules might be responsible for maintenance of psoriatic plaques. Medical hypotheses, 67 (2), 336-337 doi:10.1016/j.mehy.2006.01.051.
@article{article, year = {2006}, pages = {336-337}, DOI = {10.1016/j.mehy.2006.01.051}, keywords = {apoptosis, perforin, psoriasis}, journal = {Medical hypotheses}, doi = {10.1016/j.mehy.2006.01.051}, volume = {67}, number = {2}, issn = {0306-9877}, title = {Apoptosis mediated by cytolytic molecules might be responsible for maintenance of psoriatic plaques}, keyword = {apoptosis, perforin, psoriasis} }
@article{article, year = {2006}, pages = {336-337}, DOI = {10.1016/j.mehy.2006.01.051}, keywords = {apoptosis, perforin, psoriasis}, journal = {Medical hypotheses}, doi = {10.1016/j.mehy.2006.01.051}, volume = {67}, number = {2}, issn = {0306-9877}, title = {Apoptosis mediated by cytolytic molecules might be responsible for maintenance of psoriatic plaques}, keyword = {apoptosis, perforin, psoriasis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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