Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Synthesis of benzene and naphthalene derivatives of bis(quinone methides) (CROSBI ID 635980)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija

Sambol, Matija ; Mlinarić-Majerski, Kata ; Basarić, Nikola Synthesis of benzene and naphthalene derivatives of bis(quinone methides) // Simpozij studenata doktorskih studija PMF : knjiga sažetaka / Primožič, Ines ; Hranilović, Dubravka (ur.). Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2016. str. 44-44

Podaci o odgovornosti

Sambol, Matija ; Mlinarić-Majerski, Kata ; Basarić, Nikola

engleski

Synthesis of benzene and naphthalene derivatives of bis(quinone methides)

Some classes of anticancer antibiotics exhibit their antiproliferative activity due to metabolic formation of quinone methides (QMs) that can alkylate biologically important molecules (DNA and enzymes) [1]. However, to date, anticancer activity of simple quinone methides has not been thoroughly investigated, mostly because of their short lifetimes. A photochemical dehydration reaction of suitably substituted phenols provides a very mild and easy approach to QMs in biologically systems [2]. Herein we report synthesis of several bisQMs precursors that are anticipated to induce DNA cross-linking on photoexcitation. Precursors 1 - 10 were prepared by a Grignard reaction of appropriate dibromoalkane and protected benzene or naphthalene o- hydroxycarbaldehyde, which had to be synthesized. The target final bisphenol and bisnaphthol derivatives are new molecules that up to now have not been described in literature so they were characterized by spectroscopic methods. In addition, in vitro antiproliferative activity of the prepared bisQM precursors is going to be investigated.

quinone methides (QMs) ; anticancer activity ; benzene and naphtalene derivatives

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

44-44.

2016.

nije evidentirano

objavljeno

978-953-6076-39-0

Podaci o matičnoj publikaciji

Simpozij studenata doktorskih studija PMF : knjiga sažetaka

Primožič, Ines ; Hranilović, Dubravka

Zagreb: Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu

Podaci o skupu

Simpozij studenata doktorskih studija PMF-a

poster

26.02.2016-26.02.2016

Zagreb, Hrvatska

Povezanost rada

Kemija