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Pregled bibliografske jedinice broj: 819092

Organometallic ruthenium complexes with triphenylphosphane amino acid bioconjugates: Catalytic and biological properties


Kokan, Zoran; Brozovic, Anamaria; Piantanida, Ivo; Turel, Iztok; Kirin, Srećko I.
Organometallic ruthenium complexes with triphenylphosphane amino acid bioconjugates: Catalytic and biological properties // Book of Abstracts
Palma de Mallorca (Balearic Islands), Španjolska, 2016. str. 84-84 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Organometallic ruthenium complexes with triphenylphosphane amino acid bioconjugates: Catalytic and biological properties

Autori
Kokan, Zoran ; Brozovic, Anamaria ; Piantanida, Ivo ; Turel, Iztok ; Kirin, Srećko I.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / - , 2016, 84-84

Skup
4th Whole Action Meeting of the COST Action CM1105 and 3rd International Symposium on Functional Metal Complexes that Bind to Biomolecules

Mjesto i datum
Palma de Mallorca (Balearic Islands), Španjolska, 28.04.-29.04.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Rhodium catalyzed asymmetric hydrogenations

Sažetak
Amino acid bioconjugates of triphenlyphosphanes are successfully used as monodentate ligands in rhodium catalyzed asymmetric hydrogenations. A major feature of those metal complexes is the formation of chiral secondary structure responsible for chiral induction in the catalytic cycle. Apart from their excellent catalytic properties, organometallic ruthenium complexes with nitrogen or phosphane ligands showed promising results in cytotoxicity studies. In addition, the catalytic activity of ruthenium complexes has recently been used as a new approach to anticancer drug design. Herein, we explore the synthesis and characterization of (p-cymene)ruthenium complexes 1 and 2, bearing phosphane ligands with chiral or non-chiral amino acid esters. The spacer between the phosphorus and the amino acid was varied in order to investigate hydrogen bonding propensity of the amino acid substituents. Catalytic and biological properties will be reported.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
IP-2014-09-1461

Ustanove
Institut "Ruđer Bošković", Zagreb