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Pregled bibliografske jedinice broj: 818983

Genome-wide association study identifies 74 loci associated with educational attainment


Okbay, A.; Beauchamp, J.P.; Fontana, M.A.; ...; Kolčić, Ivana; ...; Polašek, Ozren; ...
Genome-wide association study identifies 74 loci associated with educational attainment // Nature, 533 (2016), 7604; 539-542 doi:10.1038/nature17671 (međunarodna recenzija, članak, znanstveni)


Naslov
Genome-wide association study identifies 74 loci associated with educational attainment

Autori
Okbay, A. ; Beauchamp, J.P. ; Fontana, M.A. ; ... ; Kolčić, Ivana ; ... ; Polašek, Ozren ; ...

Izvornik
Nature (0028-0836) 533 (2016), 7604; 539-542

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Gene ; education ; school

Sažetak
Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101, 069 individuals to 293, 723 individuals, and a replication study in an independent sample of 111, 349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )
HRZZ-IP-2013-11-8875 - Pleitropija, genske mreže i putevi u izoliranim ljudskim populacijama: 10.001 Dalmatinac (Ozren Polašek, )

Ustanove
Medicinski fakultet, Split

Citiraj ovu publikaciju

Okbay, A.; Beauchamp, J.P.; Fontana, M.A.; ...; Kolčić, Ivana; ...; Polašek, Ozren; ...
Genome-wide association study identifies 74 loci associated with educational attainment // Nature, 533 (2016), 7604; 539-542 doi:10.1038/nature17671 (međunarodna recenzija, članak, znanstveni)
Okbay, A., Beauchamp, J., Fontana, M., ..., Kolčić, I., ..., Polašek, O. & ... (2016) Genome-wide association study identifies 74 loci associated with educational attainment. Nature, 533 (7604), 539-542 doi:10.1038/nature17671.
@article{article, year = {2016}, pages = {539-542}, DOI = {10.1038/nature17671}, keywords = {gene, education, school}, journal = {Nature}, doi = {10.1038/nature17671}, volume = {533}, number = {7604}, issn = {0028-0836}, title = {Genome-wide association study identifies 74 loci associated with educational attainment}, keyword = {gene, education, school} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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