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Pregled bibliografske jedinice broj: 818981

Normative equations for central augmentation index: assessment of inter-population applicability and how it could be improved


Jerončić, Ana; Gunjaca, Grgo; Mrsic Dudimir, Danijela; Mudnić, Ivana; Brizic, Ivica; Polašek, Ozren; Boban, Mladen
Normative equations for central augmentation index: assessment of inter-population applicability and how it could be improved // Scientific reports, 6 (2016), 27016-27016 doi:10.1038/srep27016 (međunarodna recenzija, članak, znanstveni)


Naslov
Normative equations for central augmentation index: assessment of inter-population applicability and how it could be improved

Autori
Jerončić, Ana ; Gunjaca, Grgo ; Mrsic Dudimir, Danijela ; Mudnić, Ivana ; Brizic, Ivica ; Polašek, Ozren ; Boban, Mladen

Izvornik
Scientific reports (2045-2322) 6 (2016); 27016-27016

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Tonometry ; pulse ; analysis

Sažetak
Common reference values of arterial stiffness indices could be effective screening tool in detecting vascular phenotypes at risk. However, populations of the same ethnicity may differ in vascular phenotype due to different environmental pressure. We examined applicability of normative equations for central augmentation index (cAIx) derived from Danish population with low cardiovascular risk on the corresponding Croatian population from the Mediterranean area. Disagreement between measured and predicted cAIx was assessed by Bland-Altman analysis. Both, cAIx- age distribution and normative equation fitted on Croatian data were highly comparable to Danish low-risk sample. Contrarily, Bland-Altman analysis of cAIx disagreement revealed a curvilinear deviation from the line of full agreement indicating that the equations were not equally applicable across age ranges. Stratification of individual data into age decades eliminated curvilinearity in all but the 30–39 (men) and 40– 49 (women) decades. In other decades, linear disagreement independent of age persisted indicating that cAIx determinants other than age were not envisaged/compensated for by proposed equations. Therefore, established normative equations are equally applicable to both Nordic and Mediterranean populations but are of limited use. If designed for narrower age ranges, the equations’ sensitivity in detecting vascular phenotypes at risk and applicability to different populations could be improved.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )
HRZZ-IP-2013-11-8652 - Biološki učinci vina: utjecaj vinifikacijske tehnologije, dealkoholizacije i starenja vina (Mladen Boban, )
HRZZ-IP-2013-11-8875 - Pleitropija, genske mreže i putevi u izoliranim ljudskim populacijama: 10.001 Dalmatinac (Ozren Polašek, )

Ustanove
Medicinski fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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